(R)-(+)-Bay K8644
(R)-(+)-Bay K8644 (CAS: 98791-67-4), a trifluoromethyl-substituted dihydropyridine derivative, is a potent L-type calcium channel activator. This biologically active small molecule is primarily utilised in pharmacological research to study calcium ion flux and its role in cellular processes. Its specific action on voltage-gated calcium channels makes it an invaluable tool for investigating cell signaling, neuroscience, and cardiovascular physiology.
- IUPAC
- R-(+)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
Calcium Channel Modulation Research
Serves as a key pharmacological tool for investigating the function and regulation of L-type calcium channels. It is used to study calcium ion influx in various cell types, contributing to a deeper understanding of cellular excitability and signaling pathways.
Neuroscience and Cell Signaling Studies
Employed in neuroscience research to explore the role of calcium channels in neuronal function, neurotransmission, and synaptic plasticity. Its ability to activate calcium influx aids in dissecting complex cell signaling cascades.
Cardiovascular Physiology Investigation
Utilised to examine the effects of modulated calcium channel activity on cardiac contractility and vascular tone. This application helps in understanding cardiovascular regulation and potential therapeutic targets.
| Molecular weight | 356.30 |
|---|---|
| Empirical formula | C16H15F3N2O4 |
| Form | solid |
| Colour | yellow |
| Solubility | H2O: slightly solubleethanol: soluble (Organic solutions are stable for at least 20 days at RT.) |
| Storage temperature | 2-8°C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... ADORA3(140)rat ... Adora1(29290), Adora2a(25369) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(+)-Bay K8644 used for?
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(R)-(+)-Bay K8644 is primarily used as a research tool in pharmacology and cell biology to activate L-type calcium channels, aiding in the study of calcium ion flux, cell signaling, neuroscience, and cardiovascular physiology.
What is the CAS number and chemical formula for (R)-(+)-Bay K8644?
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The CAS number for (R)-(+)-Bay K8644 is 98791-67-4, and its empirical formula is C16H15F3N2O4.
What grade and purity does Tech Serve Solutions supply for (R)-(+)-Bay K8644?
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Tech Serve Solutions supplies (R)-(+)-Bay K8644 as a research-grade chemical. The specific purity is not stated as USP, BP, or EP, and TSS does not represent it as such.
How should (R)-(+)-Bay K8644 be handled safely?
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Handle (R)-(+)-Bay K8644 with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. It is classified as a Warning substance with hazards H315 (causes skin irritation) and H319 (causes serious eye irritation). Ensure good ventilation and follow all laboratory safety protocols.
Is (R)-(+)-Bay K8644 a controlled substance?
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The provided data does not indicate that (R)-(+)-Bay K8644 is a controlled substance.
How is (R)-(+)-Bay K8644 typically packed and exported?
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(R)-(+)-Bay K8644 is supplied as a yellow solid. For export, it is carefully packaged to maintain stability and comply with international shipping regulations for chemicals.
How can I request a quote or sample for (R)-(+)-Bay K8644?
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To request a quote or sample for (R)-(+)-Bay K8644, please contact our sales department through the website or by phone, providing your specific requirements and shipping details.
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