(R)-(+)-α-Methylbenzyl isocyanate
(R)-(+)-α-Methylbenzyl isocyanate (CAS: 33375-06-3; Formula: C6H5CH(CH3)NCO; MW: 147.17) is a chiral isocyanate reagent. It is primarily utilized as a valuable building block in asymmetric synthesis for the preparation of chiral derivatives and in enantioselective reactions. Its specific stereochemistry and reactive isocyanate group make it instrumental in introducing chirality into target molecules within chemical synthesis and research laboratories.
- IUPAC
- (R)-(+)-1-Phenylethyl isocyanate
- Synonyms
- (R)-(+)-1-Phenylethyl isocyanate
Asymmetric Synthesis
This chiral isocyanate serves as a crucial reagent in asymmetric synthesis, enabling the creation of enantiomerically enriched compounds. It is employed to introduce stereocenters and construct complex chiral molecules.
Chiral Derivatization
It is used for the derivatization of chiral amines and alcohols, facilitating their separation or analysis. The reaction with the isocyanate group forms stable urea or carbamate linkages.
Organic Synthesis
As a versatile organic building block, (R)-(+)-α-Methylbenzyl isocyanate participates in various organic transformations. Its reactive nature allows for coupling with nucleophiles to form diverse functional groups.
| Molecular weight | 147.17 |
|---|---|
| Linear formula | C6H5CH(CH3)NCO |
| Assay | 99% |
| Boiling point | 55-56 °C/2.5 mmHg(lit.) |
| Density | 1.045 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.513(lit.) |
| Optical activity | [α]20/D +10°, neat |
| Optical purity | ee: 96% (GLC) |
| Storage temperature | 2-8°C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H330Fatal if inhaled
- H334May cause allergy or asthma symptoms if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P284Wear respiratory protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 65 °C / 149 °F |
| Transport (UN / ADR) | UN 2206 6.1/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 36/37/38-42 |
| Safety statements (S) | 23-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(+)-α-Methylbenzyl isocyanate used for?
+
It is used in asymmetric synthesis as a chiral building block and for chiral derivatization of alcohols and amines. It is also employed in general organic synthesis.
What are the CAS number and chemical formula for (R)-(+)-α-Methylbenzyl isocyanate?
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The CAS number is 33375-06-3 and the chemical formula is C6H5CH(CH3)NCO.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies (R)-(+)-α-Methylbenzyl isocyanate with a minimum assay of 99%. This product is intended for research and laboratory use and is not supplied as USP, BP, EP, or pharmaceutical grade.
What are the primary safety hazards associated with this chemical?
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This chemical is dangerous and causes skin irritation (H315), serious eye irritation (H319), is toxic if inhaled (H330), may cause allergy or asthma symptoms or breathing difficulties if inhaled (H334), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including respirators and gloves, must be used. Ensure adequate ventilation.
How is (R)-(+)-α-Methylbenzyl isocyanate packed, shipped, and exported?
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Tech Serve Solutions expertly handles the packing, shipping, and global export of chemicals, adhering to all relevant regulations for hazardous materials like (R)-(+)-α-Methylbenzyl isocyanate (UN 2206, Hazard Class 6.1).
How can I request a sample or quote for (R)-(+)-α-Methylbenzyl isocyanate?
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To request a sample or quote, please contact our sales team through the website or by phone, providing the product name and CAS number (33375-06-3).
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