(R)-(+)-5,5′,6,6′,7,7′,8,8′-Octahydro-1,1′-2-naphthol
(R)-(+)-5,5′,6,6′,7,7′,8,8′-Octahydro-1,1′-2-naphthol (CAS: 65355-14-8), a chiral BINOL derivative with the molecular formula (C10H10OH)2 and a molecular weight of 294.39 g/mol. This compound is primarily recognised for its utility in asymmetric synthesis, serving as a valuable building block and ligand in stereoselective chemical transformations. Its defined stereochemistry makes it a key component in the development of enantiomerically pure pharmaceuticals and fine chemicals.
- Synonyms
- 6′,7,7′,8,8′-Octahydro-1,1′-2-naphthol(C10H10OH)2
Asymmetric Synthesis
(R)-(+)-5,5′,6,6′,7,7′,8,8′-Octahydro-1,1′-2-naphthol serves as a chiral ligand or auxiliary in various asymmetric catalytic reactions. It facilitates the stereoselective formation of new chiral centres, crucial for the synthesis of enantiomerically pure compounds.
Chiral Ligand Development
As a derivative of BINOL, this compound is employed in the design and synthesis of advanced chiral catalysts. Its rigid chiral backbone allows for the creation of highly selective catalytic systems used in complex organic synthesis.
Pharmaceutical Intermediate Synthesis
The enantiopure nature of this naphthol derivative makes it an important intermediate in the synthesis of chiral active pharmaceutical ingredients (APIs). Its application helps ensure the correct stereochemistry of drug molecules.
Fine Chemical Manufacturing
It finds application in the production of high-value fine chemicals where precise stereochemical control is paramount. This includes agrochemicals and speciality materials.
| Molecular weight | 294.39 |
|---|---|
| Linear formula | (C10H10OH)2 |
| Assay | 95% |
| Optical activity | [α]20/D +73°, c = 1 in THF |
| Melting point | 160-166 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(+)-5,5′,6,6′,7,7′,8,8′-Octahydro-1,1′-2-naphthol used for?
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This compound is primarily used in asymmetric synthesis as a chiral ligand or auxiliary, and in the development of chiral catalysts for stereoselective chemical transformations, including the synthesis of pharmaceutical intermediates and fine chemicals.
What are the CAS number and formula for (R)-(+)-5,5′,6,6′,7,7′,8,8′-Octahydro-1,1′-2-naphthol?
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The CAS number is 65355-14-8, and its linear formula is (C10H10OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product at a purity of 95% (assay). This is a research or technical grade material and is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should (R)-(+)-5,5′,6,6′,7,7′,8,8′-Octahydro-1,1′-2-naphthol be handled?
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According to GHS, this compound is a Warning with hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate personal protective equipment includes a dust mask (type N95 US), eyeshields, and gloves. Ensure good ventilation.
Is (R)-(+)-5,5′,6,6′,7,7′,8,8′-Octahydro-1,1′-2-naphthol a controlled substance?
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The provided data does not indicate that this compound is a controlled substance.
How is this chemical packed and shipped?
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Tech Serve Solutions exports chemicals globally. Specific packaging details will be provided upon inquiry, adhering to international shipping regulations.
How can I request a sample or quote?
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Please contact our sales team via the website or direct inquiry channels to request a sample or a quotation for (R)-(+)-5,5′,6,6′,7,7′,8,8′-Octahydro-1,1′-2-naphthol.
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