(R)-(−)-3,3-Dimethyl-2-butylamine
(R)-(−)-3,3-Dimethyl-2-butylamine (CAS: 66228-31-7) is a chiral amine with the molecular formula ((CH3)3C)CH(NH2)CH3 and a molecular weight of 101.19 g/mol. This optically active compound serves as a valuable chiral building block in organic synthesis. Its stereospecific properties make it particularly useful in asymmetric synthesis for creating complex molecules with defined stereochemistry, finding applications in pharmaceutical research and fine chemical production.
- IUPAC
- (R)-3,3-Dimethyl-2-aminobutane
- Synonyms
- ((CH3)3C)CH(NH2)CH3(R)-3,3-Dimethyl-2-aminobutane

Chiral Building Block
Utilised in asymmetric synthesis for the preparation of enantiomerically pure compounds. Its specific stereochemistry is crucial for introducing chirality into target molecules.
Pharmaceutical Intermediates
Serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) where precise stereochemical control is essential for drug efficacy and safety.
Organic Synthesis Reagent
Employed as a versatile reagent in various organic transformations, enabling the construction of complex molecular architectures with high stereoselectivity.
| Molecular weight | 101.19 |
|---|---|
| Linear formula | ((CH3)3C)CH(NH2)CH3 |
| Assay | ≥98.5% (GC)99% |
| Boiling point | 103 °C |
| Density | 0.762 g/mL at 25 °C |
| Refractive index | n20/D 1.4132 |
| Optical purity | enantiomeric excess: ≥98.5% |



Hazard statements
- H225Highly flammable liquid and vapour
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
- H412Harmful to aquatic life with long-lasting effects
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 2 °C / 35.6 °F |
| Transport (UN / ADR) | UN 2733 3/PG 2 |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-22-34-52/53 |
| Safety statements (S) | 16-26-36/37/39-45-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(−)-3,3-Dimethyl-2-butylamine used for?
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(R)-(−)-3,3-Dimethyl-2-butylamine is primarily used as a chiral building block in asymmetric synthesis and as an intermediate in the development of pharmaceuticals and fine chemicals, where precise stereochemical control is required.
What is the CAS number and formula for (R)-(−)-3,3-Dimethyl-2-butylamine?
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The CAS number is 66228-31-7, and its linear formula is ((CH3)3C)CH(NH2)CH3.
What grade and purity does Tech Serve Solutions supply for (R)-(−)-3,3-Dimethyl-2-butylamine?
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Tech Serve Solutions supplies (R)-(−)-3,3-Dimethyl-2-butylamine with an assay of ≥98.5% (GC) and an optical purity of enantiomeric excess ≥98.5%. We do not represent this product as USP, BP, or EP grade.
What are the primary safety hazards associated with (R)-(−)-3,3-Dimethyl-2-butylamine?
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(R)-(−)-3,3-Dimethyl-2-butylamine is classified as Danger. It is flammable (H225), harmful if swallowed (H302), causes severe skin burns and eye damage (H314), and is harmful to aquatic life with long lasting effects (H412). Appropriate personal protective equipment, including gloves, goggles, and respiratory protection, is essential.
How is (R)-(−)-3,3-Dimethyl-2-butylamine packed, shipped, and exported?
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This chemical is shipped as a UN 2733, Class 3, Packing Group II substance, reflecting its flammable and corrosive nature. Specific packaging details adhere to international shipping regulations for hazardous materials. Tech Serve Solutions is a licensed global exporter.
How can I request a quote or sample for (R)-(−)-3,3-Dimethyl-2-butylamine?
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To request a quote or sample, please visit the Tech Serve Solutions website and use the dedicated product inquiry form or contact our sales team directly. Please specify the quantity and intended use.
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