(R)-(−)-2-[2-(Diphenylphosphino)phenyl]-4-phenyl-2-oxazoline
(R)-(−)-2-[2-(Diphenylphosphino)phenyl]-4-phenyl-2-oxazoline (CAS 167171-03-1), with empirical formula C27H22NOP and molecular weight 407.44, is a key chiral ligand. Its privileged structure makes it highly valuable in asymmetric synthesis. This oxazoline-based phosphine ligand is widely employed in catalysing enantioselective transformations, contributing to the efficient production of chiral molecules for pharmaceuticals and fine chemicals. Tech Serve Solutions supplies this reagent with high purity.
![(R)-(−)-2-[2-(Diphenylphosphino)phenyl]-4-phenyl-2-oxazoline (C27H22NOP) — chemical structure, CAS 167171-03-1; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F167171-03-1.png&w=3840&q=75)
Asymmetric Catalysis
This PHOX ligand is extensively used as a catalyst or co-catalyst in a variety of enantioselective reactions, including allylic alkylations and hydrogenations. It facilitates the formation of chiral centres with high enantiomeric excess.
Organic Synthesis
Its unique structural features enable its application in complex organic syntheses, allowing for stereoselective control. It is instrumental in creating optically active compounds essential for drug discovery and development.
Metal-Catalyzed Transformations
This ligand forms stable complexes with transition metals, enhancing their catalytic activity and selectivity in reactions such as cross-couplings and cyclopropanations.
| Molecular weight | 407.44 |
|---|---|
| Empirical formula | C27H22NOP |
| Assay | ≥97.0% (31P-NMR) |
| Optical activity | [α]20/D −29.5±3°, c = 1% in chloroform |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(−)-2-[2-(Diphenylphosphino)phenyl]-4-phenyl-2-oxazoline used for?
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This compound is primarily used as a chiral ligand in asymmetric catalysis for various enantioselective organic transformations.
What is the CAS number and formula for this product?
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The CAS number is 167171-03-1 and the empirical formula is C27H22NOP.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with a minimum purity of 97.0% as determined by 31P-NMR. It is supplied for research and chemical synthesis purposes and is not represented as USP, BP, or EP grade.
How should (R)-(−)-2-[2-(Diphenylphosphino)phenyl]-4-phenyl-2-oxazoline be handled?
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Handle with appropriate personal protective equipment, including eyeshields, gloves, and a respirator filter (type N95 or P1). The compound is classified under WGK 2, indicating it is hazardous to water.
How is this chemical shipped?
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Tech Serve Solutions exports chemicals globally, ensuring appropriate packaging and documentation for safe and compliant international shipping.
How can I request a sample or quote?
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Please contact our sales team through the website to request a sample or a formal quotation for this product.
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