(R)-(−)-1,2,3,4-Tetrahydro-1-naphthol
(R)-(−)-1,2,3,4-Tetrahydro-1-naphthol (CAS: 23357-45-1) is a chiral alcohol with the molecular formula C10H12O and a molecular weight of 148.20 g/mol. This compound serves as a valuable chiral building block in organic synthesis. Its specific optical activity, [α]17/D −32°, and high optical purity (ee: 99%) make it suitable for applications requiring enantiomeric control in chemical synthesis and the development of bioactive molecules.
- IUPAC
- (R)-(−)-α-Tetralol
- Synonyms
- (R)-(−)-α-Tetralol4-Tetrahydro-1-naphthol23357-45-1C10H12O

Chiral Building Block
Utilised in asymmetric synthesis for the construction of enantiomerically pure compounds. Its defined stereochemistry is critical for developing complex chiral molecules.
Pharmaceutical Intermediate
Serves as a precursor in the synthesis of pharmacologically active compounds. Its chiral nature is often essential for drug efficacy and specificity.
Research and Development
Employed in academic and industrial research for exploring new synthetic routes and developing novel chemical entities. Particularly relevant in areas like cell biology and medicinal chemistry.
| Molecular weight | 148.20 |
|---|---|
| Empirical formula | C10H12O |
| Assay | 99% |
| Boiling point | 140 °C/17 mmHg(lit.) |
| Density | 1.09 g/mL at 25 °C(lit.) |
| Optical activity | [α]17/D −32°, c = 2.5 in chloroform |
| Optical purity | ee: 99% (HPLC) |
| Melting point | 39-40 °C(lit.) |
| Application | Chiral building block. |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... UGT2B17(7367), UGT2B7(7364) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(−)-1,2,3,4-Tetrahydro-1-naphthol used for?
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(R)-(−)-1,2,3,4-Tetrahydro-1-naphthol is primarily used as a chiral building block in asymmetric synthesis and as an intermediate in the development of bioactive molecules and pharmaceuticals.
What are the CAS number and formula for (R)-(−)-1,2,3,4-Tetrahydro-1-naphthol?
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The CAS number is 23357-45-1, and the molecular formula is C10H12O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-(−)-1,2,3,4-Tetrahydro-1-naphthol with an assay of 99% and an optical purity of ee: 99% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should (R)-(−)-1,2,3,4-Tetrahydro-1-naphthol be handled?
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Handling requires appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. The compound is a skin, eye, and respiratory irritant (H315-H319-H335).
How is (R)-(−)-1,2,3,4-Tetrahydro-1-naphthol packed, shipped, and exported?
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As a global supplier, Tech Serve Solutions expertly handles the packing, shipping, and export of fine chemicals like (R)-(−)-1,2,3,4-Tetrahydro-1-naphthol in compliance with international regulations.
How can I request a sample or quote for (R)-(−)-1,2,3,4-Tetrahydro-1-naphthol?
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To request a sample or a quotation, please contact our sales team through the website or via direct inquiry, providing your specific requirements.
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