Quin 2-AM
Quin 2-AM (CAS 83104-85-2), with the molecular formula C38H43N3O18 and a molecular weight of 829.76 g/mol, is a cell-permeable fluorescent probe. It is designed for the detection of intracellular calcium ions (Ca²⁺). This compound exhibits a significant shift in its UV absorption spectrum and a substantial increase in fluorescence upon binding to Ca²⁺, making it valuable for studying calcium signalling dynamics in biological systems.
- IUPAC
- 2-[(2-Amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester),2-{[2-Bis(carboxymethyl)amino-5-methylphenoxy]-methyl}-6-methoxy-8-bis(carboxymethyl)aminoquinoline tetrakis(acetoxymethyl) ester
Calcium Ion Detection
Quin 2-AM serves as a highly sensitive fluorescent probe for quantifying intracellular calcium (Ca²⁺) levels. Its ability to report on Ca²⁺ concentration through changes in fluorescence intensity is crucial for cell biology research.
Cell Signaling Studies
This probe is instrumental in understanding calcium signalling pathways, which play critical roles in numerous cellular processes. Researchers utilise it to investigate events like neurotransmitter release, muscle contraction, and gene expression.
Microscopy and Flow Cytometry
With its fluorescent properties, Quin 2-AM is suitable for both microscopic imaging and flow cytometry applications, allowing for spatial and temporal analysis of calcium dynamics within individual cells or cell populations.
| Molecular weight | 829.76 |
|---|---|
| Empirical formula | C38H43N3O18 |
| Assay | ≥90% |
| Storage temperature | −20°C |
| Application | Cell permeable fluorescent probe for Ca2+ that gives a large shift in the UV absorption spectrum and a 20-fold increase in fluorescence upon Ca2+ binding |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Shipped In | dry ice |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Quin 2-AM used for?
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Quin 2-AM is a cell-permeable fluorescent probe used for the detection and quantification of intracellular calcium (Ca²⁺) ions, facilitating the study of calcium signalling in biological systems.
What is the CAS number and formula for Quin 2-AM?
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The CAS number for Quin 2-AM is 83104-85-2, and its molecular formula is C38H43N3O18.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Quin 2-AM with a purity of ≥90%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety considerations for handling Quin 2-AM?
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Quin 2-AM is classified as a Warning substance, with hazard statements including H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate personal protective equipment, such as eyeshields, gloves, and suitable respiratory protection, should be used during handling. Store at -20°C.
How is Quin 2-AM shipped and exported?
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Quin 2-AM is shipped on dry ice to maintain its stability during transit and is available for global export.
How can I request a quote or sample for Quin 2-AM?
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To request a quote or sample for Quin 2-AM, please contact our sales team through the website or by phone.
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