Promethazine hydrochloride
Promethazine hydrochloride (CAS 58-33-3, C17H20N2S · HCl, MW 320.88) is a phenothiazine derivative with antihistamine and antiemetic properties. It functions as a histamine H1 receptor antagonist. This compound is widely recognised for its therapeutic applications in managing allergic reactions, motion sickness, and nausea post-operatively. It is also employed for its sedative effects. TSS supplies this chemical for research and potential therapeutic development.
- IUPAC
- 10-[2-(Dimethylamino)propyl]phenothiazine hydrochloride
- Synonyms
- 10-[2-(Dimethylamino)propyl]phenothiazine hydrochloride
Antihistamine Agent
Promethazine hydrochloride antagonises histamine H1 receptors, making it effective in alleviating symptoms associated with allergic conditions such as rhinitis and urticaria.
Antiemetic
This compound is used to prevent and treat nausea and vomiting, particularly in cases of motion sickness and post-operative recovery.
Sedative
Due to its central nervous system depressant effects, promethazine hydrochloride can be used to induce sedation and aid in managing anxiety or restlessness.
Research Chemical
Utilised in laboratory settings for studies involving histamine receptor interactions, neuropharmacology, and the development of new therapeutic agents.
| Molecular weight | 320.88 |
|---|---|
| Empirical formula | C17H20N2S · HCl |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H411Toxic to aquatic life with long-lasting effects
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 3077 9 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn,N |
| Risk statements (R) | 20/22-36/37/38-43-51/53 |
| Safety statements (S) | 22-26-28-36/37/39-60-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... HRH1(3269) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Promethazine hydrochloride used for?
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Promethazine hydrochloride is used to treat allergic reactions, motion sickness, and nausea. It also possesses sedative properties and is utilised in research settings.
What is the CAS number and chemical formula for Promethazine hydrochloride?
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The CAS number is 58-33-3 and the chemical formula is C17H20N2S · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Promethazine hydrochloride as a research-grade chemical. We do not represent it as USP, BP, or EP grade.
How should Promethazine hydrochloride be handled safely?
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Handle with appropriate personal protective equipment, including a dust mask (N95), eyeshields, face shields, and gloves. Avoid dust formation and ensure adequate ventilation. It is harmful if swallowed or inhaled, causes skin irritation, may cause an allergic skin reaction, and causes serious eye irritation, and may cause respiratory irritation. It is also toxic to aquatic life with long-lasting effects.
Is Promethazine hydrochloride a controlled substance?
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While promethazine itself is not typically a scheduled controlled substance in many jurisdictions, its use and prescription are regulated due to its pharmacological effects. Please consult local regulations for specifics.
How is Promethazine hydrochloride packed and shipped?
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Promethazine hydrochloride is carefully packed to ensure stability and safety during transit. Tech Serve Solutions exports this chemical globally, adhering to all relevant shipping regulations.
How can I request a sample or quote for Promethazine hydrochloride?
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To request a sample or quote, please contact our sales department through the website or by phone, providing your specific requirements and shipping details.
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