Potassium clavulanate
Potassium clavulanate (CAS: 61177-45-5, C8H8NO5K) is a compound derived from *Streptomyces clavuligerus*. With a molecular weight of 237.25 g/mol, it is primarily recognised for its role as a beta-lactamase inhibitor. It is frequently utilised in pharmaceutical formulations, often in conjunction with beta-lactam antibiotics, to enhance their efficacy against resistant bacterial strains. Potassium clavulanate is a white to off-white crystalline powder.
- IUPAC
- Clavulanate potassium
- Synonyms
- Clavulanate potassium
Pharmaceutical Intermediate
Potassium clavulanate serves as a crucial component in the synthesis of various antibiotic medications. Its primary function is to protect beta-lactam antibiotics from degradation by bacterial beta-lactamase enzymes, thereby broadening their spectrum of activity.
Antibiotic Augmentation
It is used in combination therapies to restore or extend the effectiveness of penicillin and cephalosporin antibiotics against bacteria that have developed resistance mechanisms. This combination approach is vital in combating challenging infections.
Biochemical Research
As a biochemical reagent, it is employed in laboratory settings to study bacterial resistance mechanisms and to develop new antimicrobial strategies. Its specific action against beta-lactamases makes it a valuable tool for researchers.
| Molecular weight | 237.25 |
|---|---|
| Empirical formula | C8H8NO5K |
| Storage temperature | 2-8°C |
| Biological source | from Streptomyces clavuligerus |
Hazard statements
- H228Flammable solid
- H252
- H319Causes serious eye irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P235Keep cool
- P305IF IN EYES
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3135 / PGII |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | F,Xi |
| Risk statements (R) | 11-14-36 |
| Safety statements (S) | 8-16-26-43 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Potassium clavulanate used for?
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Potassium clavulanate is primarily used as a beta-lactamase inhibitor in pharmaceutical applications, often combined with beta-lactam antibiotics to enhance their effectiveness against resistant bacteria.
What is the CAS number and formula for Potassium clavulanate?
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The CAS number for Potassium clavulanate is 61177-45-5, and its molecular formula is C8H8NO5K.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Potassium clavulanate as a technical/research grade chemical. We do not represent this product as USP, BP, or EP grade. Please contact us for specific assay details.
How should Potassium clavulanate be handled safely?
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Potassium clavulanate is a flammable solid and reacts violently with water. It can cause serious eye irritation. Handle with appropriate personal protective equipment, including eyeshields and gloves, and ensure it is kept away from moisture and ignition sources. Consult the Safety Data Sheet for comprehensive handling instructions.
How is Potassium clavulanate packed and shipped?
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Potassium clavulanate is shipped as a UN 3135 substance in Packing Group II. Specific packaging details for export are available upon request, adhering to relevant transportation regulations.
How can I request a sample or quote for Potassium clavulanate?
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To request a sample or a quote for Potassium clavulanate, please use the contact form on our website or reach out to our sales department directly.
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