Poly(ethylene glycol) bis(carboxymethyl) ether
Poly(ethylene glycol) bis(carboxymethyl) ether (CAS: 39927-08-7) is a homobifunctional polyethylene glycol derivative featuring terminal carboxylic acid groups. With an average molecular weight of 250 g/mol, this compound offers versatile reactivity for conjugation and crosslinking. It is valuable in materials science and polymer chemistry for modifying surfaces, creating functionalized polymers, and as a building block in organic synthesis.
- IUPAC
- Polyethylene glycol 250 diacid,Polyglycol 250 diacid

Surface Modification
Used to introduce carboxylic acid functionalities onto surfaces, enabling further covalent attachment of biomolecules or other functional groups for specialized applications in diagnostics and materials science.
Bioconjugation
Acts as a linker molecule for conjugating peptides, proteins, or small molecules in biopharmaceutical research and development, facilitating drug delivery systems or diagnostic assays.
Polymer Synthesis
Serves as a monomer or crosslinking agent in the synthesis of novel polymers with tailored properties, particularly in creating functionalized hydrogels or specialty polymers.
Materials Science
Incorporated into the development of advanced materials, such as functionalized nanoparticles or stimuli-responsive polymers, for research and industrial innovation.
| Linear formula | HOOCCH2(OCH2CH2)nOCH2COOH |
|---|---|
| Density | 1.302 g/mL at 25 °C |
| Refractive index | n20/D 1.454 |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 1760 8 / PGII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Mol Wt | average Mn 250 |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Poly(ethylene glycol) bis(carboxymethyl) ether used for?
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Poly(ethylene glycol) bis(carboxymethyl) ether is used in surface modification, bioconjugation, polymer synthesis, and various materials science applications due to its homobifunctional nature and terminal carboxylic acid groups.
What is the CAS number and formula for Poly(ethylene glycol) bis(carboxymethyl) ether?
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The CAS number is 39927-08-7 and the linear formula is HOOCCH2(OCH2CH2)nOCH2COOH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an average Mn of 250. The specific grade and purity are available upon request. We do not represent this product as USP, BP, or EP grade unless explicitly stated.
How should Poly(ethylene glycol) bis(carboxymethyl) ether be handled?
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This compound is classified as corrosive, posing a risk of severe skin burns and eye damage (H314). Appropriate personal protective equipment, including face shields, goggles, gloves, and suitable respiratory protection, must be used. Handle in a well-ventilated area and consult the Safety Data Sheet for detailed handling procedures.
How is Poly(ethylene glycol) bis(carboxymethyl) ether packed and exported?
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This chemical is packed and exported in compliance with international regulations for hazardous materials, identified as UN 1760, Hazard Class 8, Packing Group II. For specific packaging and export details, please contact our sales team.
How can I request a sample or quote for Poly(ethylene glycol) bis(carboxymethyl) ether?
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Samples and quotes can be requested by contacting the Tech Serve Solutions sales department via our website or by calling us directly. Please specify the required quantity and any particular specifications needed.
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