Piericidin A from Streptomyces mobaraensis
Piericidin A (CAS: 2738-64-9), with the molecular formula C25H37NO4, is a naturally occurring antibiotic derived from Streptomyces mobaraensis. This green-yellow liquid compound, with a molecular weight of 415.57 g/mol, is recognised for its potent biological activity. It is primarily utilised in research settings as a biochemical tool for studying cellular respiration and enzyme inhibition, particularly targeting mitochondrial complex I.
- IUPAC
- 2,6,9,11-Tridecatetraen-4-ol,13-(4-hydrox-5,6-dimethoxy-3-methyl-2-pyridyl)-3,5,7,11-tetramethyl-(all-E)-(4R,5R),4-Pyridinol,2-(10-hydroxy-3,7,9,11-tetramethyl-2,5,7,11-tridecatetraenyl)-5,6-dimethoxy- [R-[R*,R*-(all-E)]]-3-methyl-,Piericidin A1,SN 198E,Shaoguamycin B
- Synonyms
- Piericidin A1SN 198EShaoguamycin B2,6,9,11-Tridecatetraen-4-ol,13-(4-hydrox-5,6-dimethoxy-3-methyl-2-pyridyl)-3,5,7,11-tetramethyl-(all-E)-(4R,5R),4-Pyridinol,2-(10-hydroxy-3,7,9,11-tetramethyl-2,5,7,11-tridecatetraenyl)-5,6-dimethoxy- [R-[R*,R*-(all-E)]]-3-methyl-

Biochemical Research
Piericidin A is widely employed in biochemical and cell biology research to investigate mitochondrial function and cellular respiration. Its specific inhibition of NADH dehydrogenase (Complex I) makes it a valuable probe for studying electron transport chain pathways and related cellular processes.
Enzyme Inhibition Studies
As a potent inhibitor of mitochondrial complex I, Piericidin A is instrumental in studies focused on the mechanisms of enzyme inhibition and their consequences on cellular energy production. Researchers use it to dissect the roles of specific enzymes in various biological pathways.
Antifungal Agent Research
While primarily known for its mitochondrial effects, Piericidin A has also been investigated for its antifungal properties. Its antibiotic nature suggests potential applications in exploring novel treatments against fungal infections.
| Molecular weight | 415.57 |
|---|---|
| Empirical formula | C25H37NO4 |
| Assay | >95% (HPLC) |
| Form | liquid |
| Colour | green-yellow |
| Loss on drying | <10% loss on drying |
| Storage temperature | 2-8°C |

Hazard statements
- H300Fatal if swallowed
- H310Fatal in contact with skin
- H330Fatal if inhaled
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P301IF SWALLOWED
- P302IF ON SKIN
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3382 6.1 / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 26/27/28 |
| Safety statements (S) | 28-36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Shipped In | wet ice |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Piericidin A used for?
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Piericidin A is primarily used in biochemical research to study mitochondrial function, cellular respiration, and as a probe for inhibiting Complex I of the electron transport chain. It is also investigated for its antifungal properties.
What are the CAS number and formula for Piericidin A?
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The CAS number for Piericidin A is 2738-64-9, and its molecular formula is C25H37NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Piericidin A with an assay of >95% (HPLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade. This product is intended for research and laboratory use.
How should Piericidin A be handled safely?
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Piericidin A is a highly toxic substance. Handle with extreme care using appropriate personal protective equipment, including eyeshields, face shields, gloves, and a suitable respirator. Ensure adequate ventilation and avoid inhalation, ingestion, and skin contact. Refer to the safety data sheet for comprehensive handling instructions.
How is Piericidin A shipped and exported by TSS?
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Piericidin A is shipped in wet ice to maintain its stability and is exported globally by Tech Serve Solutions, adhering to all necessary regulations for hazardous materials.
How can I request a quote or sample of Piericidin A?
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To request a quote or sample of Piericidin A, please contact our sales team through the TSS website or your designated sales representative.
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