Phorbol 12,13-dibutyrate
Phorbol 12,13-dibutyrate (CAS: 37558-16-0), with the molecular formula C28H40O8 and a molecular weight of 504.61 g/mol, is a bioactive small molecule. It is recognised as a potent activator of Protein Kinase C (PKC) and is widely utilised in research for its role in cell signalling, cell biology, and cancer research, particularly concerning tumor growth regulation.
- IUPAC
- PDBu
- Synonyms
- PDBuPhorbol 12,13-dibutanoate
Cell Biology Research
Phorbol 12,13-dibutyrate serves as a valuable tool for investigating cellular processes regulated by Protein Kinase C. Its ability to activate PKC pathways aids in studying signal transduction, cell proliferation, and differentiation.
Cancer Research
This compound is employed in studies related to cancer biology due to its influence on tumor growth regulation and its capacity to act as a tumor promoter. It helps researchers explore mechanisms of carcinogenesis and potential therapeutic targets.
Cell Signaling Studies
As a specific activator of Protein Kinase C, Phorbol 12,13-dibutyrate is instrumental in dissecting complex cell signalling cascades. It allows for the examination of downstream effects mediated by PKC activation.
Neuroscience Research
Its role in cell signaling pathways extends to neuroscience, where it can be used to explore the involvement of PKC in neuronal function and related disorders.
| Molecular weight | 504.61 |
|---|---|
| Empirical formula | C28H40O8 |
| Assay | ≥98% (TLC) |
| Form | powder |
| Colour | clear, light yellow, film |
| Solubility | H2O: soluble30 μMDMSO: solubleacetone: solubleethanol: soluble |
| Storage temperature | −20°C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | mouse ... Prkcd(18753) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Phorbol 12,13-dibutyrate used for?
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Phorbol 12,13-dibutyrate is primarily used in scientific research as a potent activator of Protein Kinase C (PKC). It is applied in cell biology, cancer research, cell signaling studies, and neuroscience to investigate pathways related to cell proliferation, differentiation, and tumor growth regulation.
What is the CAS number and molecular formula for Phorbol 12,13-dibutyrate?
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The CAS number for Phorbol 12,13-dibutyrate is 37558-16-0, and its molecular formula is C28H40O8.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Phorbol 12,13-dibutyrate with an assay of ≥98% (TLC). TSS does not represent this product as USP, BP, EP, or other pharmacopoeial grades.
How should Phorbol 12,13-dibutyrate be handled safely?
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Phorbol 12,13-dibutyrate is classified as a Warning substance (GHS07) and may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). When handling, it is essential to wear appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves. Ensure good ventilation and avoid breathing dust. In case of eye contact, rinse cautiously with water for several minutes and remove contact lenses if present and easy to do. Continue rinsing.
How is Phorbol 12,13-dibutyrate packaged and shipped?
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Phorbol 12,13-dibutyrate is typically supplied as a powder. It is stored at -20°C. Tech Serve Solutions expertly handles the packaging, documentation, and export of chemicals globally.
How can I request a sample or quote for Phorbol 12,13-dibutyrate?
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To request a sample or a quote for Phorbol 12,13-dibutyrate, please contact our sales team through the website or by phone, providing the product name and CAS number (37558-16-0).
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