Phenyl N-phenylphosphoramidochloridate
Phenyl N-phenylphosphoramidochloridate (CAS: 51766-21-3), with the molecular formula C<sub>6</sub>H<sub>5</sub>NHP(O)(Cl)OC<sub>6</sub>H<sub>5</sub> and a molecular weight of 267.65 g/mol, is a versatile chemical intermediate. It is primarily employed as a reactant in the synthesis of various organic compounds, including resins, anhydrides, and heterocyclic derivatives. This compound also finds application as a catalyst in polymerisation reactions.
- IUPAC
- N-Phenylphosphoramidochloridic acid phenyl ester
Synthesis of Novel Ligands and Heterocycles
This compound serves as a key reactant for the preparation of resin-immobilized actinide ligands and thiadiaminooxopyrimidine derivatives with potential antitumor activity.
Preparation of Carboxylic Acid Derivatives
It is utilised in the synthesis of carboxylic acid anhydrides and their related derivatives, showcasing its utility in organic functional group transformations.
Polymerisation Catalyst
Phenyl N-phenylphosphoramidochloridate acts as a catalyst in various polymerisation reactions, contributing to material science applications.
Transformation of Pyrimidinones
The compound facilitates the one-pot conversion of pyrimidinones into pyrimidines, offering an efficient synthetic route for nitrogen-containing heterocycles.
Biological Studies
It has been involved in studies related to chymotrypsin binding and inhibition, suggesting potential applications in biochemical research.
| Molecular weight | 267.65 |
|---|---|
| Linear formula | C6H5NHP(O)(Cl)OC6H5 |
| Assay | ≥99% |
| Application | Reactant for synthesis of:• Resin-immobilized actinide ligands1• Carboxylic acid anhydrides and their derivatives2• Thiadiaminooxopyrimidine derivatives for antitumor activity3• Polyanhydrides via dehydrative coupling agents4Reactant for: • One-pot conversion of pyrimidinones to pyrimidines5• Conversion to alkyl Ph diester6Catalyst for polymerization reactions7Involved in biological studies for chymotrypsin binding and inhibition8 |
| Melting point | 132-134 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Phenyl N-phenylphosphoramidochloridate used for?
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Phenyl N-phenylphosphoramidochloridate is used as a reactant in organic synthesis for preparing ligands, anhydrides, and heterocyclic compounds, and as a catalyst in polymerisation reactions. It is also involved in biological studies.
What are the CAS number and molecular formula?
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The CAS number is 51766-21-3 and the molecular formula is C<sub>6</sub>H<sub>5</sub>NHP(O)(Cl)OC<sub>6</sub>H<sub>5</sub>.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Phenyl N-phenylphosphoramidochloridate with a purity of ≥99%. We do not represent this product as USP, BP, or EP grade.
How should Phenyl N-phenylphosphoramidochloridate be handled safely?
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Handle Phenyl N-phenylphosphoramidochloridate with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. Ensure adequate ventilation, as it may cause skin irritation, eye irritation, and respiratory irritation (H315, H319, H335).
How is this chemical packed and shipped?
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Tech Serve Solutions, as a global supplier and exporter, can provide detailed information on packing and shipping for Phenyl N-phenylphosphoramidochloridate upon request, adhering to all relevant regulations.
How can I request a sample or quote?
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To request a sample or quote for Phenyl N-phenylphosphoramidochloridate, please contact our sales team through the website or by phone.
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