Phenoxyacetic acid N-hydroxysuccinimide ester
Phenoxyacetic acid N-hydroxysuccinimide ester (CAS: 38678-58-9; Formula: C12H11NO5; Molar Mass: 249.22 g/mol) is a reactive chemical intermediate. It is primarily employed in synthetic organic chemistry for the introduction of the phenoxyacetyl group onto amine-containing molecules. This active ester is particularly useful in peptide chemistry and bioconjugation, facilitating the modification of biomolecules and the synthesis of complex organic structures.
- IUPAC
- Succinimidyl phenoxyacetate
- Synonyms
- Succinimidyl phenoxyacetate
Peptide Synthesis
Phenoxyacetic acid N-hydroxysuccinimide ester serves as an activated intermediate for coupling phenoxyacetic acid to amino acids or peptides. This is valuable in creating modified peptides with altered properties or for use in specific research applications.
Bioconjugation
The active ester functionality allows for efficient conjugation to primary amines found in proteins, antibodies, or other biomolecules. This enables the labelling or modification of biological targets for research and diagnostic purposes.
Organic Synthesis
As a synthetic reagent, it facilitates the phenoxyacetylation of various nucleophiles, including amines and alcohols, under mild conditions. Its use contributes to the construction of more complex organic molecules.
| Molecular weight | 249.22 |
|---|---|
| Empirical formula | C12H11NO5 |
| Grade | practical grade |
| Storage temperature | 2-8°C |
| Impurities tested | 10-20% Free N-hydroxysuccinimide |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Phenoxyacetic acid N-hydroxysuccinimide ester used for?
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Phenoxyacetic acid N-hydroxysuccinimide ester is used in organic synthesis, particularly for peptide chemistry and bioconjugation, to introduce the phenoxyacetyl group onto molecules containing amine functionalities.
What are the CAS number and formula for Phenoxyacetic acid N-hydroxysuccinimide ester?
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The CAS number is 38678-58-9, and the empirical formula is C12H11NO5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound in practical grade. It contains 10-20% free N-hydroxysuccinimide as an impurity. TSS does not represent this product as USP, BP, or EP grade.
How should Phenoxyacetic acid N-hydroxysuccinimide ester be handled and stored?
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Handle with appropriate personal protective equipment including eyeshields and gloves. Use a type N95 (US) or type P1 (EN143) respirator filter. Store at 2-8°C.
Is Phenoxyacetic acid N-hydroxysuccinimide ester a controlled substance?
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Based on the provided data, there is no indication that Phenoxyacetic acid N-hydroxysuccinimide ester is a controlled substance. Its WGK Germany classification is 3.
How are chemicals like this packed and shipped by TSS?
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Tech Serve Solutions ensures chemicals are appropriately packed for safe transit and are exported globally in compliance with regulations. Specific packaging details depend on quantity and destination.
How can I request a sample or a quote for Phenoxyacetic acid N-hydroxysuccinimide ester?
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Please contact the TSS sales team directly via our website or listed contact information to request a sample or obtain a quotation.
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