Phenoxyacetyl chloride
Phenoxyacetyl chloride (CAS: 701-99-5), with the linear formula C<sub>6</sub>H<sub>5</sub>OCH<sub>2</sub>COCl and a molecular weight of 170.59 g/mol, is a reactive organic compound. It functions as a valuable reagent in organic synthesis, particularly for generating phenyloxyketene, which is instrumental in the synthesis of β-lactams via cycloaddition reactions with imines. This compound is supplied by Tech Serve Solutions for laboratory and industrial applications.
Synthesis of β-Lactams
Phenoxyacetyl chloride is a key reagent for producing β-lactams. It generates phenyloxyketene, which subsequently undergoes cycloaddition with imines, forming the β-lactam ring structure.
Organic Synthesis Building Block
As an acid halide and carbonyl compound, phenoxyacetyl chloride serves as a versatile building block in various organic synthesis pathways, facilitating the introduction of the phenoxyacetyl moiety.
Cycloaddition Reactions
This compound is specifically employed in cycloaddition reactions, enabling the formation of cyclic structures. Its reactivity is leveraged in advanced synthetic methodologies.
| Molecular weight | 170.59 |
|---|---|
| Linear formula | C6H5OCH2COCl |
| Assay | 98% |
| Boiling point | 225-226 °C(lit.) |
| Density | 1.235 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.534(lit.) |
| Application | Reagent which generates phenyloxyketene for cycloaddition to imines leading to β-lactams.1,2 |
Hazard statements
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 108 °C / 226.4 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-34-36/37 |
| Safety statements (S) | 26-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Phenoxyacetyl chloride used for?
+
Phenoxyacetyl chloride is primarily used as a reagent to generate phenyloxyketene, which is then used in cycloaddition reactions with imines to synthesise β-lactams. It also serves as a building block in organic synthesis.
What are the CAS number and formula for Phenoxyacetyl chloride?
+
The CAS number for Phenoxyacetyl chloride is 701-99-5, and its linear formula is C<sub>6</sub>H<sub>5</sub>OCH<sub>2</sub>COCl.
What grade and purity does Tech Serve Solutions supply for Phenoxyacetyl chloride?
+
Tech Serve Solutions supplies Phenoxyacetyl chloride with an assay of 98%. TSS does not represent this product as USP, BP, or EP grade.
How should Phenoxyacetyl chloride be handled safely?
+
Phenoxyacetyl chloride is corrosive and reacts violently with water. Handle with appropriate personal protective equipment, including faceshields, goggles, gloves, and a suitable respirator. Avoid contact with skin, eyes, and clothing, and prevent exposure to moisture.
How is Phenoxyacetyl chloride packed, shipped, and exported?
+
Phenoxyacetyl chloride is packed in compliance with international shipping regulations for hazardous materials (UN 3265, Class 8, PG II). TSS offers global export services.
How can I request a sample or quote for Phenoxyacetyl chloride?
+
To request a sample or a quote for Phenoxyacetyl chloride, please contact the Tech Serve Solutions sales team via our website or direct contact details.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis