PD 0332991 isethionate
PD 0332991 isethionate (CAS: 827022-33-3) is a white to beige powder with the molecular formula C24H29N7O2 · C2H6O4S. This chemical compound serves as a potent inhibitor of cyclin-dependent kinases (CDKs), particularly CDK4/6. It is widely utilised in cell biology research for its role in regulating the cell cycle, making it a valuable tool in studies of cell proliferation and cancer.
- IUPAC
- 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one 2-hydroxy-ethanesulfonic acid (1:1),PD0332991,Palbociclib
Cell Cycle Regulation Research
PD 0332991 isethionate is a selective inhibitor of CDK4 and CDK6, crucial enzymes that regulate progression through the G1 phase of the cell cycle. Its application enables researchers to investigate the mechanisms of cell cycle control and the consequences of its disruption.
Cancer Research Tool
As a CDK inhibitor, this compound is instrumental in preclinical cancer research. It is used to study the potential of targeting CDK4/6 pathways for therapeutic intervention in various cancer types characterised by aberrant cell cycle progression.
Cell Signaling and Neuroscience Studies
This chemical finds application in exploring cell signaling pathways, particularly those involving serine/threonine kinases. Its use extends to neuroscience research where cell cycle regulation plays a role in neuronal development and function.
| Molecular weight | 573.66 |
|---|---|
| Empirical formula | C24H29N7O2 · C2H6O4S |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to beige |
| Solubility | H2O: soluble5 mg/mL, clear |
| Storage temperature | room temp |
Hazard statements
- H301Toxic if swallowed
Precautionary statements
- P301IF SWALLOWED
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25 |
| Safety statements (S) | 45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is PD 0332991 isethionate used for?
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PD 0332991 isethionate is primarily used as a selective inhibitor of cyclin-dependent kinases (CDKs) 4 and 6, making it a valuable tool in cell biology, cell cycle regulation research, and preclinical cancer studies. It is also utilised in cell signaling and neuroscience research.
What is the CAS number and formula for PD 0332991 isethionate?
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The CAS number for PD 0332991 isethionate is 827022-33-3, and its empirical formula is C24H29N7O2 · C2H6O4S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies PD 0332991 isethionate with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade; it is suitable for research and laboratory use.
How should PD 0332991 isethionate be handled?
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PD 0332991 isethionate is classified as Danger, with hazard statement H301 (Toxic if swallowed). Handle with appropriate personal protective equipment (PPE) in a well-ventilated area. In case of accidental ingestion, seek immediate medical attention. Consult the Safety Data Sheet (SDS) for comprehensive handling guidelines.
How is PD 0332991 isethionate packed and shipped?
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PD 0332991 isethionate is typically supplied as a white to beige powder. It is packed according to UN 2811 6.1 / PGIII shipping regulations for hazardous materials, suitable for global export.
How can I request a quote or sample?
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To request a quote or a sample of PD 0332991 isethionate, please contact our sales team through the TSS website or by direct inquiry. Specify the product name and CAS number for prompt service.
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