p-Tolyl isothiocyanate
p-Tolyl isothiocyanate (CAS: 622-59-3, Formula: CH3C6H4NCS, MW: 149.21) is a key organic building block and sulfur compound. This chemical is primarily utilized in complex organic synthesis, serving as a precursor or reagent in the creation of diverse molecular structures. Its specific applications include the preparation of thiourea derivatives and acting as a capping agent in peptide synthesis, making it valuable for researchers and manufacturers in the pharmaceutical and chemical industries.
- IUPAC
- 4-Methylphenyl isothiocyanate
- Synonyms
- 4-Methylphenyl isothiocyanatep-Tolyl isothiocyanate
Preparation of Thiourea Derivatives
p-Tolyl isothiocyanate is employed in synthetic routes to prepare complex thiourea compounds. An example includes its use in the synthesis of 6-[1-amino-3-(p-tolyl)-thiourea]-2-ethylbenzo[de]isoquinoline-1,3-dione.
N-Terminal Polypeptide Capping
The compound serves as an effective capping agent for the N-terminal ends of polypeptides. This application is crucial in peptide synthesis to prevent unwanted chain elongation or side reactions.
Organic Synthesis Reagent
As a versatile organic building block, p-Tolyl isothiocyanate is integral to various chemical synthesis processes. Its isothiocyanate functional group readily participates in reactions to form new chemical entities.
| Molecular weight | 149.21 |
|---|---|
| Linear formula | CH3C6H4NCS |
| Assay | 97% |
| Boiling point | 237 °C(lit.)62 °C/0.3 mmHg(lit.) |
| Refractive index | n20/D 1.6345(lit.) |
| Application | p-Tolyl isothiocyanate has been used:• in the preparation of 6-[1-amino-3-(p-tolyl)-thiourea]-2-ethylbenzo[de]isoquinoline-1,3-dione1• as capping agent to cap the N-terminal ends of polypeptides2 |
| Melting point | 25-26 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
- H334May cause allergy or asthma symptoms if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P342
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Flash point | 107 °C / 224.6 °F |
| Transport (UN / ADR) | UN 2811 6.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 36/37/38-42 |
| Safety statements (S) | 22-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is p-Tolyl isothiocyanate used for?
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p-Tolyl isothiocyanate is used in organic synthesis, including the preparation of thiourea derivatives and as a capping agent for N-terminal ends of polypeptides.
What is the CAS number and formula for p-Tolyl isothiocyanate?
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The CAS number for p-Tolyl isothiocyanate is 622-59-3, and its linear formula is CH3C6H4NCS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies p-Tolyl isothiocyanate with a minimum assay of 97%. TSS does not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should p-Tolyl isothiocyanate be handled safely?
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p-Tolyl isothiocyanate is classified as dangerous. It causes skin irritation (H315), allergic skin reaction (H317), serious eye irritation (H319), and may cause respiratory irritation (H335), and allergy or asthma symptoms or breathing difficulties if inhaled (H334). Always use appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, faceshields, and gloves. Ensure good ventilation and avoid breathing dust/fumes.
Is p-Tolyl isothiocyanate available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals like p-Tolyl isothiocyanate, serving customers worldwide.
How can I request a quote or sample of p-Tolyl isothiocyanate?
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To request a quote or sample, please contact our sales team through the website or directly via email, providing your required quantity and shipping details.
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