o-Vanillin
o-Vanillin (CAS: 148-53-8, Formula: C8H8O3, MW: 152.15) is an organic compound featuring aldehyde and hydroxyl functional groups. Also known as 2-Hydroxy-3-methoxybenzaldehyde, it serves as a valuable building block in chemical synthesis. This versatile molecule finds applications in the creation of novel ligands and in studying solvent-free reactions, making it a useful reagent for research and development in various chemical fields.
- IUPAC
- 2-Hydroxy-3-methoxybenzaldehyde,2-Hydroxy-m-anisaldehyde,3-Methoxysalicylaldehyde
- Synonyms
- 2-Hydroxy-3-methoxybenzaldehyde2-Hydroxy-m-anisaldehyde3-Methoxysalicylaldehyde

Ligand Synthesis
o-Vanillin has been utilized in the synthesis of new ligands designed for complexing with metal ions such as Fe(III) and Al(III), contributing to coordination chemistry research.
Reaction Mechanism Studies
This compound has been employed to investigate solvent-free reaction conditions, specifically in the study of reactions between o-Vanillin and p-toluidine, analysed using techniques like NMR, DSC, and XRD.
Organic Synthesis Building Block
As a functionalised aromatic aldehyde, o-Vanillin acts as a key intermediate and building block for constructing more complex organic molecules in academic and industrial research settings.
| Molecular weight | 152.15 |
|---|---|
| Linear formula | CH3OC6H3-2-(OH)CHO |
| Assay | 99% |
| Boiling point | 265-266 °C(lit.) |
| Application | o-Vanillin has been used to study the solvent-free reaction between o-vanillin and p-toluidine using NMR, DSC and XRD analysis1. It was used in the synthesis of new ligand for Fe(III) and Al(lII)2. |
| Melting point | 40-42 °C(lit.) |

Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 23-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is o-Vanillin used for?
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o-Vanillin is used as a building block in organic synthesis, in the creation of new ligands for metal ions, and for studying solvent-free reaction mechanisms.
What is the CAS number and formula for o-Vanillin?
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The CAS number for o-Vanillin is 148-53-8 and its linear formula is CH3OC6H3-2-(OH)CHO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies o-Vanillin with an assay of 99%. We do not represent this product as USP, BP, or EP grade.
How should o-Vanillin be handled?
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o-Vanillin is classified as harmful if swallowed and causes skin, eye, and respiratory irritation. Handle with appropriate personal protective equipment including a dust mask (type N95 US), eyeshields, and gloves. Ensure adequate ventilation. Precautionary statements include P261 (Avoid breathing dust) and P305 + P351 + P338 (IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing).
How is o-Vanillin packed and shipped by TSS?
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Tech Serve Solutions exports fine chemicals globally, ensuring appropriate packaging for safe transit according to international regulations.
How can I request a quote or sample for o-Vanillin?
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To request a quote or a sample of o-Vanillin, please contact our sales team through the TSS website or via direct inquiry.
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