o-Tolylmagnesium chloride solution
o-Tolylmagnesium chloride solution (CAS 33872-80-9), with the linear formula CH3C6H4MgCl and a molecular weight of 150.89, is a vital organometallic reagent. Supplied as a 1.0 M solution in THF, it is commonly employed in organic synthesis for introducing the o-tolyl group. Its reactivity makes it suitable for various carbon-carbon bond-forming reactions, crucial in the development of complex molecules across chemical research and development.
- IUPAC
- 2-Methylphenylmagnesium chloride
- Synonyms
- 2-Methylphenylmagnesium chloride
Organometallic Synthesis
This Grignard reagent is a key nucleophile in organic synthesis, facilitating the formation of new carbon-carbon bonds by reacting with electrophiles like aldehydes, ketones, and esters. It is essential for constructing complex molecular architectures.
Aryl Group Introduction
It serves as an efficient reagent for the introduction of the o-tolyl moiety into organic molecules. This is particularly useful in the synthesis of pharmaceuticals, agrochemicals, and advanced materials.
Chemical Research and Development
Utilised in R&D settings for exploratory synthesis, enabling chemists to explore novel reaction pathways and develop new chemical entities. Its predictable reactivity supports method development and proof-of-concept studies.
| Molecular weight | 150.89 |
|---|---|
| Linear formula | CH3C6H4MgCl |
| Density | 0.956 g/mL at 25 °C |
| Concentration | 1.0 M in THF |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Flash point | -16 °C / 3.2 °F |
|---|---|
| Transport (UN / ADR) | UN 3399 4.3/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14-19-34-37 |
| Safety statements (S) | 16-26-36/37/39-45 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is o-Tolylmagnesium chloride solution used for?
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o-Tolylmagnesium chloride solution is primarily used in organic synthesis to introduce the o-tolyl group and to form new carbon-carbon bonds through its reactivity as a Grignard reagent. It is valuable in chemical research and development for creating complex molecules.
What are the CAS number and formula for o-Tolylmagnesium chloride solution?
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The CAS number is 33872-80-9, and its linear formula is CH3C6H4MgCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies o-Tolylmagnesium chloride solution at a concentration of 1.0 M in THF. TSS does not represent this product as USP, BP, or EP grade.
How should o-Tolylmagnesium chloride solution be handled safely?
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This reagent is highly flammable and corrosive. It reacts violently with water and may form explosive peroxides. Handle with extreme care in a well-ventilated area, wearing appropriate personal protective equipment (gloves, eye protection) and avoiding ignition sources. Refer to the Safety Data Sheet for full details.
How is o-Tolylmagnesium chloride solution packed and shipped?
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o-Tolylmagnesium chloride solution is packed and shipped according to stringent safety regulations for hazardous materials, including specific UN classifications (UN 3399). TSS ensures compliant export procedures.
How can I request a quote or sample?
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To request a quote or sample of o-Tolylmagnesium chloride solution, please contact our sales team through the website or by phone, providing the product name and CAS number (33872-80-9).
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