o-Fluoro-DL-phenylalanine
o-Fluoro-DL-phenylalanine (CAS 2629-55-2) is a fluorinated amino acid derivative with the molecular formula FC<sub>6</sub>H<sub>4</sub>CH<sub>2</sub>CH(NH<sub>2</sub>)COOH and a molecular weight of 183.18. This compound serves as a valuable reactant in various chemical synthesis and biological studies. It is particularly useful in investigating enzymatic mechanisms, synthesising complex organic molecules, and incorporating unnatural amino acids into peptides for research purposes.
Biochemical Research
Utilised in studying the mechanisms of P 450-mediated oxidation and rearrangement reactions. It is also involved in the ribosomal translation of unnatural peptides, expanding the scope of protein engineering.
Organic Synthesis
Serves as a precursor in the conversion of racemic α-arylalanines to (<i>R</i>)-β-arylalanines. It is also employed in the synthesis of diisopropylpyridine acetamides, which are investigated for their potential as Kv1.5 potassium channel antagonists.
Resolution of Amino Acids
Applied in enantioselective hydrolysis of esters, facilitating the resolution of nonprotein amino acids. This application is crucial for obtaining enantiomerically pure compounds.
| Molecular weight | 183.18 |
|---|---|
| Linear formula | FC6H4CH2CH(NH2)COOH |
| Assay | ≥95% (NT)≥98% (HPLC)≥98% |
| Application | Reactant involved in:• Studying mechanism of P 450-mediated oxidation and rearrangement1• Conversion of racemic α-arylalanines to (R)-β-arylalanines2• Ribosomal translation of unnatural peptides3• Synthesis of diisopropylpyridine acetamides for use as Kv1.5 potassium channel antagonists4• Enantioselective hydrolysis of esters for resolution of nonprotein amino acids5 |
| Melting point | 243-246 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is o-Fluoro-DL-phenylalanine used for?
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o-Fluoro-DL-phenylalanine (CAS 2629-55-2) is used in biochemical research, including the study of P 450-mediated oxidation and ribosomal translation of unnatural peptides. It is also applied in organic synthesis for the conversion of arylalanines and the creation of potential ion channel antagonists, as well as in the enantioselective hydrolysis of esters for amino acid resolution.
What are the CAS number and molecular formula for o-Fluoro-DL-phenylalanine?
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The CAS number is 2629-55-2, and the linear formula is FC<sub>6</sub>H<sub>4</sub>CH<sub>2</sub>CH(NH<sub>2</sub>)COOH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies o-Fluoro-DL-phenylalanine with an assay of ≥95% (NT) and ≥98% (HPLC), and ≥98%. TSS does not represent this product as USP, BP, or EP grade.
What are the safety and handling precautions for o-Fluoro-DL-phenylalanine?
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Handling o-Fluoro-DL-phenylalanine requires appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. The substance is classified with a WGK Germany rating of 3, indicating a higher level of hazard in water.
How is o-Fluoro-DL-phenylalanine packaged, shipped, and exported?
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o-Fluoro-DL-phenylalanine is carefully packaged to ensure stability during transport. As a global supplier, Tech Serve Solutions exports this chemical worldwide, adhering to all relevant shipping regulations.
How can I request a sample or quote for o-Fluoro-DL-phenylalanine?
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To request a sample or a quotation for o-Fluoro-DL-phenylalanine, please contact the Tech Serve Solutions sales department via our website or direct inquiry channels.
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