Nonactin
Nonactin (CAS: 6833-84-7), a macrotetrolide antibiotic derived from Streptomyces griseus, exhibits potent ionophore activity by forming complexes with alkali cations like potassium and sodium. This compound is known to uncouple oxidative phosphorylation and inhibit the processing of cytoplasmic precursor proteins destined for mitochondria. With a molecular weight of 736.93 and formula C40H64O12, Nonactin is supplied by TSS with an assay of ≥97.0% (TLC), tested for ion specificity.
- IUPAC
- Ammonium ionophore
Ionophore for Alkali Cations
Nonactin selectively binds and transports alkali metal cations, particularly potassium and sodium, across biological membranes. This property makes it valuable in ion-selective electrode development and studies of ion transport mechanisms.
Uncoupler of Oxidative Phosphorylation
As an uncoupler, Nonactin disrupts the proton gradient across the mitochondrial membrane, inhibiting ATP synthesis. This mechanism is crucial for research into cellular energy metabolism and mitochondrial function.
Inhibitor of Protein Processing
Nonactin affects the processing of precursor proteins destined for mitochondria, suggesting a role in cellular signalling pathways and protein trafficking research. Its activity is linked to its ion-binding capabilities.
Research Reagent
Sourced from Streptomyces griseus, Nonactin serves as a vital reagent in biochemical and pharmacological research, enabling investigations into cell membrane permeability, antibiotic mechanisms, and related biological processes.
| Molecular weight | 736.93 |
|---|---|
| Empirical formula | C40H64O12 |
| Assay | ≥97.0% (TLC) |
| Storage temperature | 2-8°C |
| Application | Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is an uncoupler of oxidative phosphorylation 1. It is from Streptomyces griseus and is =98% (function tested, HPLC). |
| Biological source | from Streptomyces griseus |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Quality Level | PREMIUM |
|---|---|
| Description | Natural macrotetrolide, may contain homologues (like monactin and dinactin) |
| Quality | function tested (ion specific electrode for ammonium ions) |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Nonactin used for?
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Nonactin is used as an ionophore for alkali cations, an uncoupler of oxidative phosphorylation, and an inhibitor of mitochondrial protein precursor processing. It is also a valuable research reagent in biochemistry and pharmacology.
What are the CAS number and formula for Nonactin?
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The CAS number for Nonactin is 6833-84-7, and its empirical formula is C40H64O12.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Nonactin with a purity of ≥97.0% (TLC) and it is function tested for ion specificity. This product is intended for research purposes and TSS does not represent it as USP, BP, EP, or any other pharmacopoeia grade.
How should Nonactin be handled safely?
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When handling Nonactin, it is essential to wear appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. Refer to the safety data sheet for comprehensive handling information. It is classified under WGK Germany 3.
How is Nonactin packed and shipped?
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Nonactin is typically stored at 2-8°C. TSS ensures secure packing and adherence to all regulations for the export of fine chemicals.
How can I request a quote or sample for Nonactin?
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To request a quote or a sample of Nonactin, please contact our sales department through the TSS website or by phone.
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