(−)-Nicotine
(−)-Nicotine (CAS: 54-11-5), a C10H14N2 alkaloid with a molecular weight of 162.23 g/mol, is a naturally occurring liquid compound. Known for its significant pharmacological effects, it is primarily utilised in research settings. Its applications span investigations into neurological pathways, receptor binding studies, and as a reference standard in analytical chemistry. TSS supplies this chemical for laboratory and research purposes.
- IUPAC
- (−)-1-Methyl-2-(3-pyridyl)pyrrolidine,(S)-3-(1-Methyl-2-pyrrolidinyl)pyridine
- Synonyms
- (−)-1-Methyl-2-(3-pyridyl)pyrrolidine,(S)-3-(1-Methyl-2-pyrrolidinyl)pyridine
Neuroscience Research
Used as a tool compound to study nicotinic acetylcholine receptors (nAChRs) and their role in neurotransmission, cognitive function, and addiction research.
Pharmacological Studies
Investigated for its effects on various physiological systems and as a basis for understanding the mechanisms of action of related compounds.
Analytical Reference Standard
Employed in analytical chemistry for the identification and quantification of nicotine in various matrices, particularly in forensic and environmental testing.
Biochemical Assays
Utilised in biochemical assays to probe enzyme activity or receptor-ligand interactions within cell signaling pathways.
| Molecular weight | 162.23 |
|---|---|
| Empirical formula | C10H14N2 |
| Assay | ≥99% (GC) |
| Form | liquid |
| Colour | yellow |
| Density | 1.010 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.5265(lit.) |
| Solubility | ethanol: soluble50 mg/mL |
| Concentration | 1.0 mg/mL1.0 mg/mL±5% in methanol |
| Optical activity | [α]20/D −169°(lit.) |
| Storage temperature | 2-8°C |
Hazard statements
- H301Toxic if swallowed
- H310Fatal in contact with skin
- H400Very toxic to aquatic life
- H411Toxic to aquatic life with long-lasting effects
Precautionary statements
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P302IF ON SKIN
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 101 °C / 213.8 °F |
| Transport (UN / ADR) | UN 1654 6.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+,N |
| Risk statements (R) | 25-27-51/53 |
| Safety statements (S) | 36/37-45-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (–)-Nicotine primarily used for?
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(–)-Nicotine is primarily used in research, particularly in neuroscience and pharmacological studies, to investigate nicotinic acetylcholine receptors and their functions. It also serves as an analytical reference standard.
What are the CAS number and molecular formula for (–)-Nicotine?
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The CAS number for (–)-Nicotine is 54-11-5, and its molecular formula is C10H14N2.
What grade and purity does Tech Serve Solutions supply for (–)-Nicotine?
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Tech Serve Solutions supplies (–)-Nicotine with an assay of ≥99% (GC). We do not claim USP, BP, or EP grades unless explicitly stated in the product data.
What are the main hazards associated with handling (–)-Nicotine?
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(–)-Nicotine is acutely toxic if swallowed (H301) and toxic in contact with skin (H310), and is very toxic to aquatic life with long-lasting effects (H400, H411). Always handle with appropriate personal protective equipment in a well-ventilated area.
Is (–)-Nicotine a controlled substance?
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(–)-Nicotine is classified as Highly Toxic and an Environmentally Hazardous Substance. Its handling and distribution are subject to strict regulations in many jurisdictions.
How can I request a quote or sample for (–)-Nicotine?
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To request a quote or sample for (–)-Nicotine, please contact our sales team through the website or by phone, providing your specific requirements and shipping details.
How is (–)-Nicotine packed, shipped, and exported?
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(–)-Nicotine is packed and shipped in compliance with international regulations for hazardous materials, designated as UN 1654, Class 6.1, Packing Group II. TSS is experienced in global export of such chemicals.
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