(−)-MK-801 hydrogen maleate
(−)-MK-801 hydrogen maleate (CAS: 77086-19-2) is a chemical compound with the formula C16H15N · C4H4O4 and a molecular weight of 337.37 g/mol. This white solid is a potent non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor. It is widely utilised in neuroscience research for its ability to modulate glutamatergic neurotransmission and study conditions related to NMDA receptor dysfunction.
- IUPAC
- (5R,10S)-(–)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate
- Synonyms
- (5R,10S)-(–)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate
NMDA Receptor Antagonist Research
Serves as a critical tool in neuroscience research for investigating the role of NMDA receptors in synaptic plasticity, learning, and memory. Its non-competitive antagonism provides a specific mechanism for studying receptor function.
Neuroscience and Neurotransmission Studies
Utilised to explore complex neurological pathways and the mechanisms of neurotransmission. Researchers employ it to understand the impact of glutamate signalling on neuronal activity and disease states.
Cell Biology and Signaling Investigations
Applied in cell biology to examine cellular responses mediated by ionotropic glutamate receptors. It helps elucidate signaling cascades involved in neuronal excitability and cell death pathways.
| Molecular weight | 337.37 |
|---|---|
| Empirical formula | C16H15N · C4H4O4 |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Colour | white |
| Solubility | DMSO: >20 mg/mL |
| Optical activity | [α]25/D −117.7°, c = 1 in methanol(lit.) |
| Storage temperature | room temp |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (–)-MK-801 hydrogen maleate used for?
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(–)-MK-801 hydrogen maleate is primarily used in neuroscience research as a potent non-competitive antagonist of the NMDA receptor, helping to investigate glutamatergic neurotransmission, synaptic plasticity, and related neurological conditions.
What is the CAS number and formula for (–)-MK-801 hydrogen maleate?
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The CAS number is 77086-19-2, and the formula is C16H15N · C4H4O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (–)-MK-801 hydrogen maleate with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should (–)-MK-801 hydrogen maleate be handled and stored?
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Handle with appropriate personal protective equipment, including eyeshields, gloves, and a type N95 respirator filter. Store at room temperature. Refer to the safety data sheet for comprehensive handling and hazard information. This compound carries a WGK Germany rating of 3.
How is (–)-MK-801 hydrogen maleate packed and shipped?
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Products are carefully packed and exported according to international regulations for chemical transport. Specific packaging details can be provided upon request.
How can I request a sample or quote for (–)-MK-801 hydrogen maleate?
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To request a sample or a quote, please contact our sales department with your specific requirements. Details can be found on the Tech Serve Solutions website.
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