Niclosamide

CAS 50-65-7C13H8Cl2N2O4Biochemicals & Reagents

Niclosamide (CAS: 50-65-7), with the molecular formula C13H8Cl2N2O4 and a molecular weight of 327.12 g/mol, is a teniacide. This compound is primarily utilised for its antiparasitic properties against cestodes that infect humans. In research settings, Niclosamide is employed to study the Wnt/Frizzled-1 signaling pathway, inhibit NF-κB transcription and DNA binding in AML cells, and induce apoptosis.

IUPAC: 2′,5-Dichloro-4′-nitrosalicylanilide
Synonyms: 2',5-Dichloro-4'-nitrosalicylanilide50-65-7Niclosamide monohydrate

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Niclosamide (C13H8Cl2N2O4) — chemical structure, CAS 50-65-7; Life Science, fine chemical supplied by Tech Serve Solutions

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01 /Applications

Antiparasitic Agent

Niclosamide is an anthelmintic effective against tapeworms (cestodes) in human infections. It functions by uncoupling oxidative phosphorylation in the parasite.

Research Chemical for Signaling Pathways

Used in laboratory research to investigate the Wnt/Frizzled-1 signaling pathway. Its ability to modulate cellular signalling makes it a valuable tool for molecular biology studies.

Inhibitor of NF-κB and Inducer of Apoptosis

Niclosamide inhibits the transcription and DNA binding of NF-κB in acute myeloid leukaemia (AML) cells. It is also utilised to induce apoptosis in experimental models.

02 /Properties

Molecular weight	327.12
Empirical formula	C13H8Cl2N2O4
Application	Niclosamide is a teniacide in the anthelmintic family. It is effective against cestodes that infect humans. Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It is used to inhibit the transcription and DNA binding of NF-κB in AML cells and ito induce apoptosis1.

03 /Safety & handling

GHS hazard pictogram: Environmental hazard (GHS09) — Environmental hazard

Warning

Hazard statements

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Transport (UN / ADR)	UN 3077 9 / PGIII
Water hazard class (WGK, DE)	2

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

50-65-7

MDL number

MFCD00057597

Beilstein registry

2820605

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Niclosamide used for?

Niclosamide is a teniacide used to treat tapeworm infections in humans. In research, it is used to study signaling pathways like Wnt/Frizzled-1, inhibit NF-κB, and induce apoptosis.

What is the CAS number and formula for Niclosamide?

The CAS number for Niclosamide is 50-65-7, and its empirical formula is C13H8Cl2N2O4.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Niclosamide for research purposes. The specific grade and purity are detailed on the product's Certificate of Analysis. We do not represent this product as USP, BP, or EP grade.

How should Niclosamide be handled safely?

Niclosamide is classified as H400 (Very toxic to aquatic life). Handle with care, using appropriate personal protective equipment including eyeshields, gloves, and a type N95 or P1 respirator filter. Ensure proper disposal to avoid environmental release.

How is Niclosamide packaged and shipped?

Niclosamide is packaged according to regulatory standards for chemical transport. It is shipped internationally by Tech Serve Solutions, adhering to UN 3077 9 / PGIII regulations for environmentally hazardous substances.

How can I request a sample or quote for Niclosamide?

To request a sample or quote for Niclosamide, please contact our sales team through the website or by phone. Provide your contact details and the quantity required.