Naratriptan hydrochloride
Naratriptan hydrochloride (CAS: 143388-64-1), with the empirical formula C17H25N3O2S ·HCl and a molecular weight of 371.93 g/mol, is a white to off-white powder. This compound serves as a selective serotonin 5-HT1B/1D receptor agonist. It is primarily recognised for its application in the pharmaceutical industry as a therapeutic agent, specifically in the development and manufacturing of migraine treatments.
- IUPAC
- Amerge,GR-85548A,N-Methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide hydrochloride
- Synonyms
- N-Methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide hydrochloride
Pharmaceutical Intermediate
Naratriptan hydrochloride is a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) for migraine treatment. Its specific pharmacological action targets serotonin receptors involved in the regulation of vascular tone in cranial blood vessels.
Research and Development
This compound is utilized in research settings to study serotonin receptor pathways and their role in neurological processes. It is valuable for investigating potential new therapeutic targets and drug candidates within neuroscience and pharmacology.
Migraine Therapy Agent
As a serotonin 5-HT1B/1D receptor agonist, Naratriptan hydrochloride is the active component in certain medications designed to alleviate migraine symptoms. It functions by constricting dilated cranial blood vessels and inhibiting the release of inflammatory neuropeptides.
| Molecular weight | 371.93 |
|---|---|
| Empirical formula | C17H25N3O2S ·HCl |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to off-white |
| Solubility | H2O: ≥10 mg/mL |
| Storage temperature | room temp |
Hazard statements
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Naratriptan hydrochloride used for?
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Naratriptan hydrochloride is used as a pharmaceutical intermediate in the development of migraine treatments and is recognised for its role as a selective serotonin 5-HT1B/1D receptor agonist in therapeutic applications.
What is the CAS number and formula for Naratriptan hydrochloride?
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The CAS number for Naratriptan hydrochloride is 143388-64-1, and its empirical formula is C17H25N3O2S ·HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Naratriptan hydrochloride with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade unless explicitly stated.
How should Naratriptan hydrochloride be handled?
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Handle Naratriptan hydrochloride with care. It is classified as a Warning substance with H319 hazard statement (Causes serious eye irritation). Ensure adequate ventilation and wear protective gloves, eye protection, and face protection. In case of contact with eyes, rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P305 + P351 + P338.
Is Naratriptan hydrochloride a controlled substance?
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The provided data does not indicate that Naratriptan hydrochloride is a controlled substance.
How is Naratriptan hydrochloride shipped and exported?
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Naratriptan hydrochloride is typically shipped and exported at room temperature. TSS is an experienced global supplier and exporter of fine chemicals.
How can I request a sample or quote for Naratriptan hydrochloride?
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To request a sample or quote for Naratriptan hydrochloride, please contact the Tech Serve Solutions sales team via our website or by telephone.
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