N,N-Dimethylformamide dineopentyl acetal
N,N-Dimethylformamide dineopentyl acetal (CAS 4909-78-8) is a chemical compound with the linear formula (CH₃)₂NCH[OCH₂C(CH₃)₃]₂ and a molecular weight of 231.37 g/mol. This acetal serves as a valuable reagent in organic synthesis. Its primary applications include esterification reactions and the synthesis of various organic compounds, such as barbiturate derivatives and specifically labelled amino acids.
- IUPAC
- 1,1-Dineopentyloxytrimethylamine,1,1-Dineopentyloxy-N,N-dimethylmethylamine
- Synonyms
- (CH3)2NCH[OCH2C(CH3)3]21,1-Dineopentyloxytrimethylamine1,1-Dineopentyloxy-N,N-dimethylmethylamine
![N,N-Dimethylformamide dineopentyl acetal ((CH3)2NCH[OCH2C(CH3)3]2) — chemical structure, CAS 4909-78-8; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F4909-78-8.png&w=3840&q=75)
Esterification of Fmoc Amino Acids
N,N-Dimethylformamide dineopentyl acetal has been utilised in the esterification of Nα-9-fluorenylmethyloxycarbonylamino acids (Fmoc). This application is crucial in peptide synthesis for protecting amino acid functionalities.
Synthesis of Barbiturate Derivatives
The compound serves as a reagent in the synthesis of 1,3-dialkyl, benzyl, and cyclohexyl barbiturate derivatives. This highlights its utility in the construction of complex heterocyclic structures.
Stereospecific Synthesis of Amino Acids
It is employed as a reagent during the stereospecific synthesis of L-serine and L-cystine, particularly when deuterium labelling is required at the beta-position.
| Molecular weight | 231.37 |
|---|---|
| Linear formula | (CH3)2NCH[OCH2C(CH3)3]2 |
| Assay | 99% |
| Boiling point | 85-87 °C/10 mmHg(lit.) |
| Density | 0.829 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.412(lit.) |
| Application | N,N-Dimethylformamide dineopentyl acetal was used in the esterification of Nα-9-fluorenylmethyloxycarbonylamino acids(Fmoc)1. It was used in the synthesis of 1,3-dialkyl, benzyl and cyclohexyl barbiturate derivatives2. It was used as reagent during the synthesis of L-serine and L-cystine stereospecifically labeled with deuterium at the β-position3. |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 52 °C / 125.6 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N,N-Dimethylformamide dineopentyl acetal used for?
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N,N-Dimethylformamide dineopentyl acetal is used in organic synthesis, including the esterification of Fmoc amino acids, the synthesis of barbiturate derivatives, and the stereospecific synthesis of labelled amino acids like L-serine and L-cystine.
What is the CAS number and formula for N,N-Dimethylformamide dineopentyl acetal?
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The CAS number is 4909-78-8 and the linear formula is (CH₃)₂NCH[OCH₂C(CH₃)₃]₂.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N,N-Dimethylformamide dineopentyl acetal with a purity of 99% (assay). We do not represent this product as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated in the product data.
How should N,N-Dimethylformamide dineopentyl acetal be handled?
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N,N-Dimethylformamide dineopentyl acetal is a flammable liquid and vapour (H226) and can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including eyeshields and gloves, and ensure adequate ventilation. Avoid contact with skin, eyes, and clothing. Keep away from heat, sparks, and open flames.
Is this chemical controlled or scheduled?
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The provided data does not indicate that N,N-Dimethylformamide dineopentyl acetal is a controlled or scheduled substance. However, users should always verify compliance with local regulations.
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions packs and ships chemicals in compliance with all relevant international transportation regulations. As a global supplier and exporter, we ensure appropriate packaging for safe transit.
How can I request a sample or quote?
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To request a sample or a quote for N,N-Dimethylformamide dineopentyl acetal, please contact our sales department through the website or by phone. Our team will be happy to assist you.
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