N,N-Diisopropylmethylamine
N,N-Diisopropylmethylamine (CAS 10342-97-9) is a tertiary amine with a molecular weight of 115.22 g/mol. Characterised by its organic base properties, it serves as a valuable reagent in chemical synthesis. It is frequently employed as a non-nucleophilic base and a proton scavenger in various organic reactions, facilitating transformations where strong, sterically hindered bases are required. Its utility spans diverse synthetic methodologies within organic chemistry research and development.
- IUPAC
- N-Methyldiisopropylamine
- Synonyms
- N-Methyldiisopropylamine[(CH3)2CH]2NCH3
![N,N-Diisopropylmethylamine ([(CH3)2CH]2NCH3) — chemical structure, CAS 10342-97-9; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F10342-97-9.png&w=3840&q=75)
Non-Nucleophilic Base in Organic Synthesis
N,N-Diisopropylmethylamine acts as a sterically hindered, non-nucleophilic base, ideal for deprotonation reactions where nucleophilic attack by the base must be avoided. This is crucial in preventing unwanted side reactions during the synthesis of complex organic molecules.
Proton Scavenger
This amine is effective at scavenging protons generated during acid-sensitive reactions, helping to drive reactions to completion and maintain optimal conditions for product formation. It is particularly useful in reactions involving highly reactive intermediates.
Reagent in Pharmaceutical Intermediate Synthesis
Its role as a base and scavenger makes it a useful reagent in the multi-step synthesis of pharmaceutical intermediates, contributing to the efficient construction of target drug molecules.
| Molecular weight | 115.22 |
|---|---|
| Linear formula | [(CH3)2CH]2NCH3 |
| Assay | ≥98.0% (GC) |
| Density | 0.754 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.411(lit.) |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 10 °C / 50 °F |
| Transport (UN / ADR) | UN 2733 3/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-34 |
| Safety statements (S) | 16-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N,N-Diisopropylmethylamine used for?
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N,N-Diisopropylmethylamine is primarily used as a non-nucleophilic base and proton scavenger in organic synthesis, particularly in the preparation of pharmaceutical intermediates and other fine chemicals.
What is the CAS number and formula for N,N-Diisopropylmethylamine?
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The CAS number for N,N-Diisopropylmethylamine is 10342-97-9, and its linear formula is [(CH3)2CH]2NCH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N,N-Diisopropylmethylamine with an assay of ≥98.0% (GC). This product is supplied for research and laboratory use. TSS does not represent this product as meeting USP, BP, EP, or other pharmacopoeial standards.
How should N,N-Diisopropylmethylamine be handled safely?
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N,N-Diisopropylmethylamine is flammable (Flash Point 10 °C) and causes severe skin burns and eye damage. Handle with appropriate personal protective equipment, including gloves, eye protection, and respiratory protection, in a well-ventilated area, away from ignition sources. Refer to the Safety Data Sheet (SDS) for full details.
Is N,N-Diisopropylmethylamine a controlled substance?
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The provided data does not indicate that N,N-Diisopropylmethylamine is a controlled substance.
How is N,N-Diisopropylmethylamine packed, shipped, and exported?
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N,N-Diisopropylmethylamine is shipped according to international regulations for hazardous materials. TSS is a specialist global supplier and exporter experienced in handling and shipping fine chemicals worldwide.
How can I request a sample or quote for N,N-Diisopropylmethylamine?
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To request a sample or a quotation, please contact the TSS sales team via the website or by phone, providing the product name and CAS number.
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