N-Ethyldiisopropylamine
N-Ethyldiisopropylamine (CAS: 7087-68-5) is a sterically hindered, non-nucleophilic organic base with the linear formula CH3CH2N[CH(CH3)2]2 and a molecular weight of 129.24 g/mol. Commonly known as Hünig's base, it is widely utilised as an acid scavenger in organic synthesis. Its bulky nature prevents it from acting as a nucleophile, making it ideal for promoting reactions without unwanted side products. It is supplied by TSS with an assay of ≥98.0%.
- IUPAC
- N,N-Diisopropylethylamine,Hünigs base
- Synonyms
- N,N-DiisopropylethylamineHünigs base
![N-Ethyldiisopropylamine (CH3CH2N[CH(CH3)2]2) — chemical structure, CAS 7087-68-5; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F7087-68-5.png&w=3840&q=75)
Acid Scavenger in Organic Synthesis
N-Ethyldiisopropylamine effectively neutralises acidic by-products generated during various organic reactions, such as alkylations, acylations, and silylations. Its steric hindrance prevents it from participating as a nucleophile, ensuring cleaner reaction profiles and higher yields of desired products.
Base in Elimination Reactions
This hindered amine can be employed to promote elimination reactions where a strong, non-nucleophilic base is required. It facilitates the removal of leaving groups without competing nucleophilic attack, crucial for synthesising specific olefins.
Protecting Group Chemistry
In complex multi-step syntheses, N-Ethyldiisopropylamine is used to facilitate the introduction and removal of protecting groups. Its basicity aids in the formation of silyl ethers and other protecting functionalities.
| Molecular weight | 129.24 |
|---|---|
| Linear formula | CH3CH2N[CH(CH3)2]2 |
| Assay | ≥98.0% (GC) |
| Boiling point | 126-128 °C(lit.) |
| Density | 0.755 g/mL at 20 °C(lit.)0.757 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.454 |
| Concentration | ~2 M in 1-methyl-2-pyrrolidinone |
| Impurities tested | ≤0.2% water (KFT) |
Hazard statements
- H225Highly flammable liquid and vapour
- H301Toxic if swallowed
- H314Causes severe skin burns and eye damage
- H412Harmful to aquatic life with long-lasting effects
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 10 °C / 50 °F |
| Transport (UN / ADR) | UN 2733 3/PG 2 |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-22-34-52/53 |
| Safety statements (S) | 16-26-36/37/39-45-60 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Ethyldiisopropylamine used for?
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N-Ethyldiisopropylamine is primarily used as a sterically hindered, non-nucleophilic organic base and acid scavenger in organic synthesis. It is valuable in reactions like alkylations, acylations, and silylations where neutralising acidic by-products without unwanted nucleophilic interference is critical.
What is the CAS number and formula for N-Ethyldiisopropylamine?
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The CAS number for N-Ethyldiisopropylamine is 7087-68-5, and its linear formula is CH3CH2N[CH(CH3)2]2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-Ethyldiisopropylamine with a minimum assay of ≥98.0% (GC). Impurities, such as water, are limited to ≤0.2% (KFT). TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should N-Ethyldiisopropylamine be handled safely?
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N-Ethyldiisopropylamine is a dangerous substance classified under GHS02, GHS05, and GHS06 with the signal word 'Danger'. It is highly flammable (H225), toxic if swallowed (H301), causes severe skin burns and eye damage (H314), and is harmful to aquatic life with long-lasting effects (H412). Appropriate personal protective equipment, including full-face respirators, gloves, and eye protection, is essential. Handle only in well-ventilated areas away from ignition sources.
Is N-Ethyldiisopropylamine a controlled substance?
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The provided data does not indicate that N-Ethyldiisopropylamine is a controlled substance.
How is N-Ethyldiisopropylamine packed and exported?
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N-Ethyldiisopropylamine is shipped as UN 2733, Class 3, Packing Group II. Detailed specifications for packing and export are available upon request.
How can I request a sample or quote for N-Ethyldiisopropylamine?
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To request a sample or a quote for N-Ethyldiisopropylamine, please contact the Tech Serve Solutions sales team through our website or by phone. Our experts will be pleased to assist you.
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