N-Methyl-4-piperidinol
N-Methyl-4-piperidinol (CAS: 106-52-5), with the molecular formula C6H13NO and a molecular weight of 115.17 g/mol, is a heterocyclic organic compound. It functions as a key building block in chemical synthesis. Its primary applications include serving as a reactant in the development of antitumor agents, histamine H4 receptor antagonists, and various kinase inhibitors, underscoring its significance in medicinal chemistry research.
- IUPAC
- 1-Methyl-4-piperidinol,4-Hydroxy-1-methylpiperidine
- Synonyms
- 1-Methyl-4-piperidinol4-Hydroxy-1-methylpiperidine
Antitumor Agent Development
N-Methyl-4-piperidinol is utilised as a reactant in the optimisation of the Novobiocin scaffold, contributing to the synthesis of novel antitumor agents.
Histamine H4 Receptor Antagonist Synthesis
This compound serves as a reactant for substitutions around a rigidifying ring, crucial for the synthesis of histamine H4 receptor antagonists.
Kinase Inhibitor Synthesis
It is employed as a reactant in the synthetic pathways for various kinase inhibitors, including those targeting VEGFR, FGFR, and phosphoinositide-3-kinase.
Protein Lysine Methyltransferase Inhibitors
N-Methyl-4-piperidinol is a reactant in the synthesis of inhibitors for the protein lysine methyltransferase G9a.
CaMKII Inhibitor Synthesis
This molecule is a reactant in the synthetic routes leading to CaMKII inhibitors.
| Molecular weight | 115.17 |
|---|---|
| Empirical formula | C6H13NO |
| Assay | 98% |
| Boiling point | 200 °C(lit.) |
| Refractive index | n20/D 1.4775(lit.) |
| Storage temperature | 2-8°C |
| Application | Reactant for:• Optimization of Novobiocin scaffold to product antitumor agents1• Substitution about the rigidifying ring for histamine H4 receptor antagonist synthesis2Reactant for synthesis of:• CaMKII inhibitors3• VEGFR and FGFR kinase inhibitors4• Phosphoinositide-3-kinase inhibitors5• Protein lysine methyltransferase G9a inhibitors6 |
| Melting point | 29-31 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 112 °C / 233.6 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 37/38-41 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Methyl-4-piperidinol primarily used for?
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N-Methyl-4-piperidinol is primarily used as a reactant in the synthesis of various pharmaceutical agents, including antitumor agents, histamine H4 receptor antagonists, and kinase inhibitors.
What are the CAS number and chemical formula for N-Methyl-4-piperidinol?
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The CAS number for N-Methyl-4-piperidinol is 106-52-5, and its chemical formula is C6H13NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-Methyl-4-piperidinol with a minimum assay of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety considerations for handling N-Methyl-4-piperidinol?
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N-Methyl-4-piperidinol is classified as Danger, with hazards including skin irritation (H315), serious eye damage (H318), and respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields and gloves, must be used. Handle in a well-ventilated area.
How is N-Methyl-4-piperidinol shipped and exported?
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Tech Serve Solutions, as a specialist global supplier and exporter, handles the packing and shipping of N-Methyl-4-piperidinol in compliance with all relevant regulations for international distribution.
How can I request a quote or sample of N-Methyl-4-piperidinol?
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To request a quote or sample of N-Methyl-4-piperidinol, please contact our sales department through the provided channels on our website.
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