N-Boc-2-aminophenol
N-Boc-2-aminophenol (CAS: 186663-74-1) is an organic building block with the molecular formula HOC<sub>6</sub>H<sub>4</sub>NHCO<sub>2</sub>C(CH<sub>3</sub>)<sub>3</sub> and a molecular weight of 209.24. This protected aminophenol derivative is valuable in synthetic organic chemistry. It serves as a crucial intermediate in the construction of more complex molecules, particularly in pharmaceutical research and fine chemical synthesis where the Boc protecting group facilitates selective reactions.
- IUPAC
- 2-Hydroxyphenyl carbamic acid tert-butyl ester,N-tert-Butoxycarbonyl-2-aminophenol
- Synonyms
- 2-tert-Butoxycarbonylaminophenoltert-Butyl (2-hydroxyphenyl)carbamate
Pharmaceutical Intermediate
N-Boc-2-aminophenol is employed as a key building block in the multi-step synthesis of active pharmaceutical ingredients (APIs). Its structure allows for further functionalisation and elaboration in drug discovery programs.
Organic Synthesis Reagent
In research and development settings, this compound functions as a versatile reagent for introducing the 2-aminophenol moiety with a protected amine. It is useful for constructing heterocyclic compounds and other complex organic structures.
Fine Chemical Production
It serves as an intermediate in the production of various fine chemicals. The tert-butoxycarbonyl (Boc) protecting group can be readily removed under acidic conditions, enabling subsequent reactions at the amine nitrogen.
| Molecular weight | 209.24 |
|---|---|
| Linear formula | HOC6H4NHCO2C(CH3)3 |
| Assay | 97% |
| Melting point | 140-144 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/38-43 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Boc-2-aminophenol used for?
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N-Boc-2-aminophenol is primarily used as a building block and intermediate in organic synthesis, particularly for pharmaceutical research and the production of fine chemicals. It is valuable for introducing a protected 2-aminophenol structure into complex molecules.
What are the CAS number and molecular formula for N-Boc-2-aminophenol?
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The CAS number for N-Boc-2-aminophenol is 186663-74-1, and its linear molecular formula is HOC<sub>6</sub>H<sub>4</sub>NHCO<sub>2</sub>C(CH<sub>3</sub>)<sub>3</sub>.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-Boc-2-aminophenol with a minimum assay of 97%. This product is suitable for research and chemical synthesis purposes. Tech Serve Solutions does not represent this product as USP, BP, or EP grade.
How should N-Boc-2-aminophenol be handled safely?
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N-Boc-2-aminophenol is classified as a Warning substance (GHS07) and may cause skin irritation (H315), allergic skin reaction (H317), and serious eye irritation (H319). When handling, use a dust mask type N95 (US), wear eyeshields, faceshields, and gloves. Ensure adequate ventilation and avoid dust formation.
Is N-Boc-2-aminophenol exported by Tech Serve Solutions?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including N-Boc-2-aminophenol, serving customers worldwide.
How can I request a sample or quote for N-Boc-2-aminophenol?
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To request a sample or a quote for N-Boc-2-aminophenol, please contact the Tech Serve Solutions sales team via our website or direct enquiry channels.
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