β,γ-Methyleneguanosine 5′-triphosphate sodium salt
β,γ-Methyleneguanosine 5′-triphosphate sodium salt (CAS: 10470-57-2) is a non-hydrolyzable analogue of GTP. This compound is valuable for studying GTP binding and hydrolysis in various biological processes. It is used to investigate GTP-dependent cellular signalling, protein synthesis, and metabolic pathways, offering a stable alternative to GTP in research settings.
- IUPAC
- GMPPCP,GppCp,Guanosine-5′-[(β,γ)-methyleno]triphosphate sodium salt
- Synonyms
- GMPPCPGppCpGuanosine-5′-[(β,γ)-methyleno]triphosphate sodium salt
G Protein Modulation
GMPPCP is employed to study the role of G proteins in cell signalling pathways. Its non-hydrolyzable nature allows for the stable binding and investigation of G protein activation, inhibition, and downstream effects.
Enzyme Kinetics and Mechanism Studies
As a stable GTP analogue, GMPPCP can be used to investigate the kinetics and mechanisms of enzymes that interact with GTP, including those involved in energy transduction and signal amplification.
Protein Synthesis Research
This compound can be utilized in studies examining the mechanisms of protein synthesis where GTP hydrolysis is a critical step, providing insights into the process without the complexity of transient GTP hydrolysis.
Nucleotide Binding Assays
GMPPCP serves as a useful tool for assays designed to measure nucleotide binding to proteins or other macromolecules, due to its stability and ability to mimic GTP binding.
| Molecular weight | 521.21 (free acid basis) |
|---|---|
| Empirical formula | C11H18N5O13P3 · xNa+ |
| Assay | ≥98% (HPLC) |
| Storage temperature | −20°C |
| Application | βγ-Methyleneguanosine 5′-triphosphate (GMPPCP, GppCp) is a non-hydrolyzable analog of GTP used in a variety of applications that involve GTP binding including GTP-activation, GTP-inhibition, GTP transport, GTP hydrolysis and GTP structure stabilization. GMPPCP (GuoPP[CH2MP) is used to modulate and study G proteins involved in cell signaling, protein synthesis and other metabolic processes. |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is β,γ-Methyleneguanosine 5′-triphosphate sodium salt used for?
+
β,γ-Methyleneguanosine 5′-triphosphate sodium salt is used as a non-hydrolyzable analogue of GTP in biochemical research. It is applied to study GTP binding, activation, inhibition, transport, hydrolysis, and stabilization of structures involving GTP, particularly in modulating and studying G proteins involved in cell signalling, protein synthesis, and metabolic processes.
What are the CAS number and molecular formula?
+
The CAS number is 10470-57-2. The empirical formula (Hill notation) is C11H18N5O13P3 · xNa+.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies β,γ-Methyleneguanosine 5′-triphosphate sodium salt with a purity of ≥98% (HPLC). TSS does not represent this product as USP, BP, EP, or any pharmacopoeia grade.
What are the safety and handling requirements?
+
The safety data indicates a WGK Germany classification of 3. Handle with appropriate personal protective equipment in a well-ventilated area. Refer to the Safety Data Sheet (SDS) for detailed handling and hazard information.
How is this chemical shipped and exported?
+
This chemical is shipped and exported according to international regulations for chemical transport, typically requiring cold storage during transit. Please contact us for specific export documentation and requirements.
How can I request a sample or quote?
+
To request a sample or a quotation, please visit our website or contact our sales department directly with your inquiry.
▶ Related products
![(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (C8H13N3O4) — chemical structure, CAS 138472-01-2; Biochemicals & Reagents, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F138472-01-2.png&w=3840&q=75)
(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide
C8H13N3O4
Biochemicals & Reagents![(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide (C14H18N4O4) — chemical structure, CAS 162626-99-5; Biochemicals & Reagents, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F162626-99-5.png&w=3840&q=75)
(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide
C14H18N4O4
Biochemicals & Reagents
(±)-2,5-Dimethoxy-4-bromoamphetamine hydrobromide
Biochemicals & Reagents
(±)-2-(p-Methoxyphenoxy)propionic acid
C10H12O4
Biochemicals & Reagents
(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide
C10H13NO2·HBr
Biochemicals & Reagents
(±)-2-Hydroxydecanoic acid
C10H20O3
Biochemicals & Reagents
(±)-3-Hydroxydecanoic acid
C10H20O3
Biochemicals & Reagents
(±)-3-Hydroxyoctanoic acid
C8H16O3
Biochemicals & Reagents▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis