1-Chloro-3,5-difluorobenzene

CAS 1435-43-4ClC6H3F2Chemical Synthesis

1-Chloro-3,5-difluorobenzene (CAS: 1435-43-4) is a fluorinated aromatic compound with the molecular formula C6H3F2Cl. It serves as a valuable building block in organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. Its specific halogenation pattern makes it a useful intermediate for introducing difluorophenyl moieties into more complex molecules, contributing to altered chemical and biological properties.

Synonyms: 1-Chloro-3,5-difluorobenzeneClC6H3F2

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1-Chloro-3,5-difluorobenzene (ClC6H3F2) — chemical structure, CAS 1435-43-4; Chemistry, fine chemical supplied by Tech Serve Solutions

ArylBuilding BlocksChemical SynthesisFluorinated Building BlocksHalogenated HydrocarbonsOrganic Building Blocks

01 /Applications

Pharmaceutical Intermediate

This compound is employed in the synthesis of active pharmaceutical ingredients (APIs), where the difluorobenzene unit can influence drug efficacy and metabolic stability. It is a key precursor for various complex organic molecules used in medicinal chemistry research and drug discovery.

Agrochemical Synthesis

1-Chloro-3,5-difluorobenzene is utilised in the production of advanced agrochemicals, such as herbicides and pesticides. The incorporation of fluorine atoms can enhance the biological activity and environmental persistence of these agricultural products.

Materials Science

The unique electronic properties conferred by the fluorine and chlorine substituents make this compound a potential building block in the development of novel organic materials. It can be incorporated into polymers or functional organic molecules for specialized applications.

Research and Development

As a versatile fluorinated building block, 1-Chloro-3,5-difluorobenzene is frequently used in academic and industrial research laboratories. It facilitates the exploration of new chemical transformations and the synthesis of novel compounds with tailored properties.

02 /Properties

Molecular weight	148.54
Linear formula	ClC6H3F2
Assay	95%
Boiling point	111-112 °C(lit.)
Density	1.329 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.465(lit.)

03 /Safety & handling

GHS hazard pictogram: Flammable (GHS02) — Flammable

Warning

Hazard statements

H226Flammable liquid and vapour

Protective equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Flash point	29 °C / 84.2 °F
Transport (UN / ADR)	UN 1993C 3 / PGIII
Water hazard class (WGK, DE)	2
Risk statements (R)	10

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

1435-43-4

MDL number

MFCD00041518

PubChem substance

24878209

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 1-Chloro-3,5-difluorobenzene used for?

1-Chloro-3,5-difluorobenzene is primarily used as a building block in organic synthesis, particularly for the development of pharmaceuticals, agrochemicals, and advanced organic materials. It is also widely employed in research and development laboratories.

What is the CAS number and molecular formula for 1-Chloro-3,5-difluorobenzene?

The CAS number for 1-Chloro-3,5-difluorobenzene is 1435-43-4, and its linear formula is ClC6H3F2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 1-Chloro-3,5-difluorobenzene with an assay of 95%. We do not represent this product as USP, BP, or EP grade.

How should 1-Chloro-3,5-difluorobenzene be handled?

1-Chloro-3,5-difluorobenzene is a flammable liquid and vapour (H226) requiring careful handling. Users should wear appropriate personal protective equipment, including eyeshields, faceshields, gloves, and suitable respiratory protection. Store away from heat, sparks, and open flames.

Is 1-Chloro-3,5-difluorobenzene a controlled substance?

The provided data does not indicate that 1-Chloro-3,5-difluorobenzene is a controlled substance.

How is 1-Chloro-3,5-difluorobenzene packed and shipped?

1-Chloro-3,5-difluorobenzene is shipped as UN 1993, Class 3, Packing Group III, adhering to international transport regulations for hazardous materials.

How can I request a sample or quote for 1-Chloro-3,5-difluorobenzene?

To request a sample or a quotation for 1-Chloro-3,5-difluorobenzene, please contact our sales team through the TSS website or via email, providing your specific requirements.