1-Chloro-3-iodopropane
1-Chloro-3-iodopropane (CAS: 6940-76-7, Formula: Cl(CH2)3I) is a halogenated hydrocarbon and organic building block. With a molecular weight of 204.44 g/mol, this compound serves as a valuable intermediate in organic synthesis. It is utilised in the construction of complex molecules, including pharmaceutical intermediates and novel heterocyclic compounds. Supplied by Tech Serve Solutions, it is a key reagent for researchers and industrial chemists requiring precise molecular architectures.
- IUPAC
- Trimethylene chloroiodide
- Synonyms
- Trimethylene chloroiodide
Synthesis of Enzyme Inhibitors
1-Chloro-3-iodopropane has been employed in the synthesis of inhibitors for glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide ribonucleotide transformylase (AICAR Tfase), crucial enzymes in purine biosynthesis.
Construction of Quinolines
This reagent has been used in the creation of 'proton sponge' type molecules within the quinoline family, demonstrating its utility in developing specialised heterocyclic structures.
Organic Synthesis Intermediate
As a bifunctional haloalkane, 1-chloro-3-iodopropane is a versatile building block for introducing propyl chains in organic molecules through various coupling reactions.
| Molecular weight | 204.44 |
|---|---|
| Linear formula | Cl(CH2)3I |
| Assay | 99% |
| Boiling point | 170-172 °C(lit.) |
| Density | 1.904 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.548(lit.) |
| Vapour pressure | 2 mmHg (20 °C) |
| Vapour density | 6.8 (vs air) |
| Contains / stabiliser | copper as stabilizer |
| Application | 1-Chloro-3-iodopropane has been used in the synthesis of:• N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid, an inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide ribonucleotide transformylase (AICAR Tfase)1• interesting ″proton sponge″ type molecule quino[7,8-h]quinoline2 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 110 °C / 230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Chloro-3-iodopropane used for?
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1-Chloro-3-iodopropane is used as an intermediate in organic synthesis, including the preparation of enzyme inhibitors and heterocyclic compounds.
What are the CAS number and formula for 1-Chloro-3-iodopropane?
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The CAS number is 6940-76-7 and the formula is Cl(CH2)3I.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Chloro-3-iodopropane with an assay of 99%. This product is intended for research and laboratory use and is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should 1-Chloro-3-iodopropane be handled safely?
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1-Chloro-3-iodopropane is a Warning substance that causes skin irritation, serious eye irritation, and may cause respiratory irritation. Appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, should be used. Handle in a well-ventilated area. Refer to the Safety Data Sheet for comprehensive handling guidelines.
Is 1-Chloro-3-iodopropane a controlled substance?
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The provided data does not indicate that 1-Chloro-3-iodopropane is a controlled substance.
How are chemicals from Tech Serve Solutions packed and shipped?
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Tech Serve Solutions packs and exports chemicals in compliance with international shipping regulations to ensure safe transit globally.
How can I request a quote or sample for 1-Chloro-3-iodopropane?
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To request a quote or sample, please contact our sales team through the Tech Serve Solutions website or by calling our customer service line.
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