3-Iodothiophene
3-Iodothiophene (CAS: 10486-61-0; C4H3IS; MW: 210.04) is a halogenated heterocyclic compound. This thiophene derivative serves as a versatile building block in organic synthesis, particularly in the preparation of functionalised thiophenes and conjugated polymers. Its reactive iodine atom allows for facile participation in cross-coupling reactions and organometallic chemistry, making it valuable for research and development in materials science and pharmaceuticals.

Organometallic Reagent Synthesis
3-Iodothiophene is a precursor for generating organometallic reagents, such as 3-thienylzinc iodide. This intermediate can then be used in subsequent cross-coupling reactions with aryl halides.
Polymer Synthesis
It is employed in the synthesis of specific thiophene derivatives like 3-(perfluorooctyl)thiophene. This monomer is essential for the preparation of conductive polymers, such as poly(3-perfluorooctylthiophene).
Heterocyclic Chemistry
As a halogenated heterocycle, 3-Iodothiophene is a useful starting material for introducing the thiophene moiety into more complex molecular structures.
| Molecular weight | 210.04 |
|---|---|
| Empirical formula | C4H3IS |
| Assay | ≥97% |
| Boiling point | 75 °C/14 mmHg(lit.) |
| Density | 2.066 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.657(lit.) |
| Storage temperature | 2-8°C |
| Contains / stabiliser | copper as stabilizer |
| Application | 3-Iodothiophene was used in the synthesis of 3-thienylzinc iodide via reaction with zinc, followed by coupling with aryl halides1. It was also used in the preparation of 3-(perfluorooctyl)thiophene, required for the synthesis of poly(3-perfluorooctylthiophene) conjugated polymer2. |
| Protective equipment | Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | 78 °C / 172.4 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Iodothiophene used for?
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3-Iodothiophene is primarily used as a building block in organic synthesis for creating functionalised thiophenes and polymers, and for generating organometallic reagents.
What are the CAS number and molecular formula for 3-Iodothiophene?
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The CAS number is 10486-61-0, and the molecular formula is C4H3IS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Iodothiophene with an assay of ≥97%. We do not represent this product as USP, BP, or EP grade.
How should 3-Iodothiophene be handled and stored?
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3-Iodothiophene is combustible and has a relatively high flash point. It should be stored at 2-8°C. Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, should be used when handling.
Is 3-Iodothiophene available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 3-Iodothiophene.
How can I request a quote or sample for 3-Iodothiophene?
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Please contact our sales team via the website or by phone to request a quote or sample for 3-Iodothiophene.
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