Methyl N,N,N′,N′-tetraisopropylphosphorodiamidite

CAS 92611-10-4N′Catalysis & Inorganic

Methyl N,N,N′,N′-tetraisopropylphosphorodiamidite (CAS 92611-10-4) is a phosphorodiamidite compound with the molecular formula C13H30N2OP. Possessing a molecular weight of 262.37 g/mol, this chemical serves as a valuable reagent in organic synthesis, particularly in nucleoside chemistry and as a coupling reagent. Its structure features a central phosphorus atom bonded to a methoxy group and two diisopropylamino groups, enabling specific reactivity in chemical transformations.

IUPAC: Bis(diisopropylamino)methoxyphosphine;
Synonyms: N′-tetraisopropylphosphorodiamidite,92611-10-4, [[(CH3)2CH]2N]2POCH3, Bis(diisopropylamino)methoxyphosphine

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Methyl N,N,N′,N′-tetraisopropylphosphorodiamidite (N′) — chemical structure, CAS 92611-10-4; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical BiologyChemical SynthesisCoupling ReagentsNucleoside ChemistryPhosphine Compounds

01 /Applications

Nucleoside Chemistry

Methyl N,N,N′,N′-tetraisopropylphosphorodiamidite is employed in the synthesis of nucleosides and nucleotides. It facilitates the formation of phosphite triester linkages, crucial for creating modified nucleic acid structures for research and therapeutic applications.

Coupling Reagent

This compound functions as an effective coupling reagent in various organic synthesis pathways. Its reactivity allows for the efficient formation of new chemical bonds, making it useful in the construction of complex molecules.

Phosphorus Precursor

As a source of trivalent phosphorus, it can be utilized in reactions requiring the introduction of phosphorus-containing moieties. This is particularly relevant in the development of new organophosphorus compounds with diverse applications.

Chemical Synthesis Intermediate

It serves as a versatile intermediate in multi-step chemical syntheses. Its specific functional groups enable controlled transformations and the creation of target molecules in research and development settings.

02 /Properties

Molecular weight	262.37
Linear formula	[[(CH3)2CH]2N]2POCH3
Assay	97%
Boiling point	74-75 °C/0.45 mmHg(lit.)
Density	0.915 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.461(lit.)

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Flash point	87 °C / 188.6 °F
Transport (UN / ADR)	NA 1993 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	14-36/37/38
Safety statements (S)	7-26-36
Supplemental hazards	Reacts violently with water.

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

92611-10-4

MDL number

MFCD00451020

PubChem substance

24864467

Beilstein registry

4291461

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Methyl N,N,N′,N′-tetraisopropylphosphorodiamidite used for?

Methyl N,N,N′,N′-tetraisopropylphosphorodiamidite is used in organic synthesis, particularly in nucleoside chemistry as a coupling reagent and as a phosphorus precursor in the synthesis of organophosphorus compounds.

What are the CAS number and formula for Methyl N,N,N′,N′-tetraisopropylphosphorodiamidite?

The CAS number is 92611-10-4, and its linear formula is [[(CH3)2CH]2N]2POCH3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Methyl N,N,N′,N′-tetraisopropylphosphorodiamidite with an assay of 97%. This product is supplied for research and development purposes and is not represented as USP, BP, EP, or pharmacopoeia grade.

How should Methyl N,N,N′,N′-tetraisopropylphosphorodiamidite be handled safely?

This compound is a Warning chemical that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). It reacts violently with water. Appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, must be worn. Handle in a well-ventilated area and avoid contact with water.

How is Methyl N,N,N′,N′-tetraisopropylphosphorodiamidite packed, shipped, and exported?

Tech Serve Solutions packs, ships, and exports chemicals in compliance with all relevant international regulations. For bulk quantities or specific packaging requirements, please contact our sales team.

How can I request a sample or quote for Methyl N,N,N′,N′-tetraisopropylphosphorodiamidite?

To request a sample or a quote, please use the contact form on our website or email our sales department directly with your inquiry and specifications.