Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate
Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate (CAS 680-15-9) is a fluorinated organic building block with the linear formula FSO2CF2CO2CH3 and a molecular weight of 192.11 g/mol. This compound serves as a valuable reagent in organic synthesis, particularly for introducing difluoromethyl and perfluoroalkyl groups into various substrates. Its utility spans the synthesis of complex fluorinated molecules.
- IUPAC
- Difluoro(fluorosulfonyl)acetic acid methyl ester
- Synonyms
- FSO2CF2CO2CH3Difluoro(fluorosulfonyl)acetic acid methyl ester
Difluoromethylation Reagent
Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate is employed as a reagent for the difluoromethylation of alkyl halides, enabling the introduction of the CF2H moiety into organic structures.
Perfluoroalkylation of Aryl Halides
This compound is applicable for the perfluoroalkylation of aryl iodides and bromides, facilitating the synthesis of fluorinated aromatic compounds.
Fluorinated Building Block
As a versatile building block, it is utilized in the construction of complex molecules containing specific fluorinated functionalities, crucial in pharmaceuticals and materials science.
| Molecular weight | 192.11 |
|---|---|
| Linear formula | FSO2CF2CO2CH3 |
| Assay | 97% |
| Boiling point | 117-118 °C(lit.) |
| Density | 1.509 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.351(lit.) |
| Application | • Useful reagent for the trifluoromethylation of alkyl halides.1,2• Broadly applicable reagent for perfluoroalkylations for aryl iodides and bromides2 |
Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 47 °C / 116.6 °F |
| Transport (UN / ADR) | UN 2920 3(8) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate used for?
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Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate is used as a reagent for difluoromethylation of alkyl halides and perfluoroalkylation of aryl halides, serving as a key building block in organic synthesis.
What is the CAS number and formula for Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate?
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The CAS number is 680-15-9 and the linear formula is FSO2CF2CO2CH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate with an assay of 97%. TSS does not represent this product as USP, BP, EP or other pharmacopoeia grades unless explicitly stated.
How should Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate be handled safely?
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This compound is a Danger hazard, flammable (Flash Point 47 °C), and causes severe skin burns and eye damage (H314). Handle with extreme caution, using appropriate personal protective equipment including gloves, goggles, face shields, and respiratory protection suitable for corrosive and flammable vapours.
Is this chemical packed and exported by TSS?
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Yes, Tech Serve Solutions, established in 1998, is a specialist global supplier and exporter of fine chemicals, including Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate.
How can I request a sample or quote?
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Please contact our sales team directly to inquire about samples or to request a quotation for Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate.
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