Methoxypolyethylene glycol 5,000 acetic acid N-succinimidyl ester
Methoxypolyethylene glycol 5,000 acetic acid N-succinimidyl ester (CAS: 92451-01-9) is a functionalised polymer derived from polyethylene glycol. It features a terminal methoxy group and an N-succinimidyl ester group, making it reactive towards primary amines. This bifunctional nature allows for conjugation to biomolecules and surfaces, finding utility in materials science and polymer chemistry for modifying properties or creating new materials.
- IUPAC
- Succinimidyl ester of carboxymethyl-PEG,mono-Methyl polyethylene glycol 5′000 acetic acid N-succinimidyl ester
- Synonyms
- Succinimidyl carboxymethyl-PEG methyl etherPEG-NHS esterMethoxypolyethylene glycol acetic acid succinimidyl ester
Bioconjugation
The N-succinimidyl ester moiety readily reacts with amine groups found on proteins, peptides, and other biomolecules. This enables the covalent attachment of the PEG chain to enhance solubility, reduce immunogenicity, or facilitate targeted delivery.
Surface Modification
This compound can be used to functionalise surfaces, such as nanoparticles or sensor chips, by immobilising the PEG chain. This can alter surface properties, improve biocompatibility, or create platforms for immobilising other molecules.
Polymer Synthesis
As a monofunctional PEG derivative, it can serve as an end-capping agent or initiating species in polymerisation processes, introducing PEG chains with specific terminal functionalities into larger polymer structures.
| Assay | ≥80% (NMR)≥80% |
|---|---|
| Storage temperature | −20°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Mol Wt | PEG average Mn 5,000 |
|---|---|
| Shipped In | wet ice |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methoxypolyethylene glycol 5,000 acetic acid N-succinimidyl ester used for?
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It is primarily used for bioconjugation, surface modification, and in polymer synthesis, enabling the attachment of PEG chains to biomolecules or surfaces and the creation of functionalised polymers.
What is the CAS number and formula?
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The CAS number is 92451-01-9. The chemical formula is not explicitly provided but it is a derivative of polyethylene glycol with an average molecular weight of 5,000.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of ≥80% (NMR) and ≥80%. It is supplied as a technical/research grade material and is not represented as USP, BP, or EP grade.
What are the safety and handling considerations?
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Appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter, should be used when handling this chemical. It is classified with WGK Germany 3.
How is this product shipped and stored?
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This product is shipped in wet ice and should be stored at -20°C.
How can I request a sample or quote?
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Please contact Tech Serve Solutions sales team to request a sample or obtain a quote for this product.
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