MES hemisodium salt
MES hemisodium salt (CAS: 117961-21-4, Formula: C6H13NO4S·0.5Na, MW: 206.73) is a white to off-white dry powder. As a zwitterionic buffering agent, it maintains stable pH in biological and biochemical research applications, particularly within the useful range of pH 5.5 to 6.7. Its properties make it suitable for applications in molecular biology, proteomics, and electrophoresis.
- IUPAC
- 2-(N-Morpholino)ethanesulfonic acid hemisodium salt,4-Morpholineethanesulfonic acid hemisodium salt

Biological Buffering
This MES salt serves as a biological buffer, maintaining stable pH conditions essential for enzymatic assays, cell culture, and other sensitive biological experiments within its effective pKa range.
Molecular Biology and Proteomics
It is widely employed in molecular biology and proteomics for applications such as protein electrophoresis and western blotting, where precise pH control is critical for sample integrity and experimental reproducibility.
Electrophoresis
The compound is utilised in electrophoresis buffers to ensure consistent ion mobility and stable pH gradients, facilitating accurate separation of biomolecules.
| Molecular weight | 206.73 |
|---|---|
| Empirical formula | C6H13NO4S·0.5Na |
| Assay | ≥98% (titration) |
| Form | dry powder |
| Impurities tested | ≤8% water content (Karl Fischer) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Cation traces | Pb: ≤5 ppm |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Pka  | 6.1 |
|---|---|
| Useful Ph Range | 5.5 - 6.7 |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is MES hemisodium salt used for?
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MES hemisodium salt is used as a biological buffer in research applications, including molecular biology, proteomics, and electrophoresis, maintaining pH in the range of 5.5-6.7.
What are the CAS number and formula for MES hemisodium salt?
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The CAS number is 117961-21-4 and the empirical formula is C6H13NO4S·0.5Na.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies MES hemisodium salt with an assay of ≥98% (titration), and a water content of ≤8% (Karl Fischer). This product is supplied for research and technical use and is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should MES hemisodium salt be handled safely?
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When handling MES hemisodium salt, wear appropriate personal protective equipment including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if respiratory protection is needed. The substance has a WGK rating of 3, indicating it is hazardous to water.
How is MES hemisodium salt packed and shipped?
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MES hemisodium salt is supplied as a dry powder. TSS is a global supplier and exporter, capable of shipping this chemical worldwide according to relevant regulations.
How can I request a sample or quote for MES hemisodium salt?
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To request a sample or a quote for MES hemisodium salt, please contact our sales team through the website or by phone.
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