Leptomycin B solution from Streptomyces sp.
Leptomycin B solution (CAS: 87081-35-4, C33H48O6) is a potent antibiotic and antifungal agent derived from Streptomyces sp. With a molecular weight of 540.73 g/mol, this PREMIUM grade compound is recognised for its ability to inhibit nuclear-localization signals and affect nuclear transport. It is essential for research in cell biology, gene regulation, and neuroscience, particularly in studies involving protein import/export and the regulation of gene expression.
Cell Biology Research
Leptomycin B is a key tool for studying nuclear transport mechanisms, including the import and export of proteins. Its selective inhibition of the CRM1 (XPO1) export receptor aids in understanding cellular localization and function.
Gene Regulation Studies
This compound is utilised to investigate the role of nuclear transport in gene expression. By blocking the export of specific mRNA and proteins, researchers can elucidate pathways controlling cellular responses.
Neuroscience Applications
Leptomycin B aids in the investigation of neuronal function by influencing protein trafficking and signalling pathways within the central nervous system, contributing to research in neurodegenerative diseases.
Antifungal and Antibiotic Research
As an antibiotic and antifungal agent, Leptomycin B is employed in screening for new therapeutic agents and understanding microbial resistance mechanisms.
| Molecular weight | 540.73 |
|---|---|
| Empirical formula | C33H48O6 |
| Assay | ≥95% (HPLC) |
| Storage temperature | −20°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H331Toxic if inhaled
- H370Causes damage to organs
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P311Call a POISON CENTER or doctor
| Flash point | 18 °C / 64.4 °F |
|---|---|
| Transport (UN / ADR) | UN 1230 3/PG 2 |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | F,T |
| Risk statements (R) | 11-23/24/25-39/23/24/25 |
| Safety statements (S) | 16-36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Quality Level | PREMIUM |
|---|---|
| Shipped In | dry ice |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Leptomycin B solution used for?
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Leptomycin B solution is primarily used in research for studying cell biology, particularly nuclear transport mechanisms, gene regulation, and neuroscience. It also exhibits antifungal and antibiotic properties.
What are the CAS number and formula for Leptomycin B solution?
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The CAS number for Leptomycin B solution is 87081-35-4 and its empirical formula is C33H48O6.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Leptomycin B solution at a PREMIUM quality level with an assay of ≥95% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should Leptomycin B solution be handled safely?
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Leptomycin B solution is a danger substance. It is highly flammable and toxic if swallowed, in contact with skin, or if inhaled (H225-H301-H311-H331-H370). Handle with extreme care in a well-ventilated area, wearing appropriate protective equipment (gloves, eye protection, respiratory protection). Ensure adequate measures against electrostatic discharges. Refer to the Safety Data Sheet for comprehensive handling guidelines.
How is Leptomycin B solution shipped and exported?
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Leptomycin B solution is shipped and exported using dry ice to maintain its required storage temperature of -20°C.
How can I request a quote or sample for Leptomycin B solution?
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To request a quote or sample for Leptomycin B solution, please contact our sales team through the website or by phone, providing your specific requirements.
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