Leflunomide
Leflunomide (CAS: 75706-12-6), with the chemical formula C12H9F3N2O2 and a molecular weight of 270.21 g/mol, is a potent immunosuppressant. It functions as an inhibitor of dihydroorotate dehydrogenase (DHODH), an enzyme crucial for pyrimidine synthesis. This mechanism makes it valuable in managing autoimmune conditions, including rheumatoid arthritis and inflammatory bowel disease, and in preventing organ transplant rejection.
- IUPAC
- 5-Methylisoxazole-4-(4-trifluoromethyl)carboxanilide
Immunosuppression in Organ Transplantation
Leflunomide is utilised to mitigate the immune response following organ transplantation, thereby reducing the risk of graft rejection. Its immunosuppressive properties aid in managing the recipient's immune system.
Treatment of Rheumatoid Arthritis
This compound is an established therapy for rheumatoid arthritis, helping to control inflammation and joint damage. It addresses the autoimmune processes that characterise the condition.
Management of Autoimmune Diseases
Beyond rheumatoid arthritis, leflunomide demonstrates efficacy in treating other autoimmune disorders. It modulates immune system activity to alleviate symptoms and disease progression.
| Molecular weight | 270.21 |
|---|---|
| Empirical formula | C12H9F3N2O2 |
| Storage temperature | 2-8°C |
| Application | By virtue of its immunosuppressant effects, leflunomide has found use in organ transplantation1 and treatment of rheumatoid arthritis2 and other autoimmune diseases. |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... DHODH(1723) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Leflunomide primarily used for?
+
Leflunomide is primarily used for its immunosuppressant effects in managing rheumatoid arthritis, other autoimmune diseases, and in preventing organ transplant rejection.
What are the CAS number and chemical formula for Leflunomide?
+
The CAS number for Leflunomide is 75706-12-6, and its chemical formula is C12H9F3N2O2.
What grade and purity does Tech Serve Solutions supply for Leflunomide?
+
Tech Serve Solutions supplies Leflunomide for research purposes. The specific grade and purity available are detailed in our product specifications. We do not represent this product as meeting USP, BP, or EP pharmacopoeial standards.
How should Leflunomide be handled safely?
+
Leflunomide is classified as dangerous. It is toxic if swallowed (H301), causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask type N95, eyeshields, faceshields, and gloves, must be worn during handling. Ensure good ventilation. In case of accidental exposure, follow P261, P301 + P310, and P305 + P351 + P338 procedures.
How is Leflunomide packed, shipped, and exported by TSS?
+
Leflunomide is typically packed in appropriate containers to ensure stability and safety during transit. Tech Serve Solutions is experienced in exporting fine chemicals globally, adhering to all relevant shipping regulations, including UN 2811 for hazardous materials.
How can I request a sample or quote for Leflunomide?
+
To request a sample or a quote for Leflunomide, please contact our sales department through the website or by phone, providing your specific requirements and contact details.
▶ Related products
![(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (C8H13N3O4) — chemical structure, CAS 138472-01-2; Biochemicals & Reagents, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F138472-01-2.png&w=3840&q=75)
(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide
C8H13N3O4
Biochemicals & Reagents![(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide (C14H18N4O4) — chemical structure, CAS 162626-99-5; Biochemicals & Reagents, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F162626-99-5.png&w=3840&q=75)
(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide
C14H18N4O4
Biochemicals & Reagents
(±)-2,5-Dimethoxy-4-bromoamphetamine hydrobromide
Biochemicals & Reagents
(±)-2-(p-Methoxyphenoxy)propionic acid
C10H12O4
Biochemicals & Reagents
(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide
C10H13NO2·HBr
Biochemicals & Reagents
(±)-2-Hydroxydecanoic acid
C10H20O3
Biochemicals & Reagents
(±)-3-Hydroxydecanoic acid
C10H20O3
Biochemicals & Reagents
(±)-3-Hydroxyoctanoic acid
C8H16O3
Biochemicals & Reagents▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis