L-β-Homothreonine
L-β-Homothreonine (CAS: 192003-00-2), with the molecular formula C5H11NO3, is a non-proteinogenic amino acid. It is a structural analogue of threonine, featuring an extended beta-carbon chain. This compound serves as a valuable building block in chemical synthesis, particularly in peptide chemistry and the exploration of unnatural amino acid derivatives for applications in chemical biology and drug discovery.
- IUPAC
- (3R,4R)-3-Amino-4-hydroxypentanoic acid
Chemical Synthesis
L-β-Homothreonine is employed as a chiral building block in the synthesis of complex organic molecules and peptidomimetics. Its unique structure allows for the introduction of novel side chains and conformational constraints in target molecules.
Peptide Chemistry
As an unnatural beta-amino acid, it can be incorporated into peptide sequences to study the effects of structural modifications on peptide folding, stability, and biological activity. This aids in the development of modified peptides with enhanced therapeutic properties.
Chemical Biology Research
This compound is used in research settings to investigate biochemical pathways and protein structure-function relationships. Its incorporation can yield probes for studying biological systems or serve as a tool for developing enzyme inhibitors.
Drug Discovery
L-β-Homothreonine serves as a scaffold for the design and synthesis of novel therapeutic agents. Its derivatives can be explored for potential pharmacological activities in various disease areas.
| Molecular weight | 133.15 |
|---|---|
| Empirical formula | C5H11NO3 |
| Assay | ≥98.0% (TLC) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is L-β-Homothreonine used for?
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L-β-Homothreonine is primarily used in chemical synthesis, peptide chemistry, chemical biology research, and drug discovery as a building block for creating unnatural amino acid derivatives and peptidomimetics.
What is the CAS number and formula for L-β-Homothreonine?
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The CAS number for L-β-Homothreonine is 192003-00-2, and its empirical formula is C5H11NO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies L-β-Homothreonine with a purity of ≥98.0% (TLC). This product is suitable for research and chemical synthesis; TSS does not represent it as USP, BP, or EP grade.
How should L-β-Homothreonine be handled safely?
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L-β-Homothreonine is a Warning substance that may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). When handling, wear a dust mask type N95 (US), eyeshields, and gloves. Ensure adequate ventilation and avoid dust formation.
Is L-β-Homothreonine a controlled substance?
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The provided data does not indicate that L-β-Homothreonine is a controlled substance.
How is L-β-Homothreonine packed and shipped?
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L-β-Homothreonine is carefully packed according to industry standards to ensure safe transit and is exported globally by Tech Serve Solutions.
How can I request a quote or sample?
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To request a quote or a sample of L-β-Homothreonine, please contact the Tech Serve Solutions sales team through our website or by phone.
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