L-Amethopterin hydrate
L-Amethopterin hydrate (CAS 133073-73-1), molecular formula C20H22N8O5 · xH2O, is a high-purity chemical supplied by Tech Serve Solutions for chemical synthesis applications, to pharmacopoeia specification (USP, BP, EP). Every batch is tested and ships with a Certificate of Analysis; MSDS and technical data sheets are available on request. Tech Serve Solutions has supplied laboratory reagents, fine chemicals and pharmaceutical intermediates worldwide since 1998.
- IUPAC
- 4-Amino-10-methylfolic acid hydrate,L-4-Amino-N10-methylpteroylglutamic acid hydrate,L-Amethopterin hydrate,Antifolan hydrate,MTX hydrate,Methotrexate hydrate,Methylaminopterin hydrate
| Molecular weight | 454.44 (anhydrous basis) |
|---|---|
| Empirical formula | C20H22N8O5 · xH2O |
| Assay | 98% |
| Solubility | H2O: insoluble |
| Optical activity | [α]25/D +17°, c = 1 in 0.05 M Na2CO3 |
| Storage temperature | −20°C |
| Application | Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites. |
| Suitability | meets USP testing specifications |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H360May damage fertility or the unborn child
Precautionary statements
- P201Obtain special instructions before use
- P301IF SWALLOWED
- P305IF IN EYES
- P308IF exposed or concerned
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 1544 6.1/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 61-25-36/38 |
| Safety statements (S) | 53-26-36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... DHFRP1(573971), FPGS(2356), SLC19A1(6573), TYMS(7298)mouse ... Dhfr(13361)rat ... Dhfr(24312) |
|---|
Documentation
Supplied to USP, BP and EP standards. Every batch ships with a Certificate of Analysis (assay, identity, purity); MSDS and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is L-Amethopterin hydrate?
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L-Amethopterin hydrate (CAS 133073-73-1), molecular formula C20H22N8O5 · xH2O, is a high-purity chemical supplied by Tech Serve Solutions for chemical synthesis applications, to USP, BP and EP standards.
What grades of L-Amethopterin hydrate does Tech Serve Solutions supply?
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Tech Serve Solutions supplies L-Amethopterin hydrate in USP, BP, EP and reagent/AR grades. Custom specifications for nutraceutical or specialty pharmaceutical applications are available — contact our technical sales team.
What is the CAS number and molecular formula of L-Amethopterin hydrate?
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L-Amethopterin hydrate has CAS number 133073-73-1 and molecular formula C20H22N8O5 · xH2O. Full specifications appear in the table above and in the Certificate of Analysis.
What is the typical minimum order quantity and lead time for L-Amethopterin hydrate?
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Sample quantities are available for technical evaluation; bulk MOQ depends on grade and packaging. In-stock material typically ships in 7–10 working days; custom-spec orders take 3–4 weeks. Tech Serve Solutions ships worldwide with full export documentation.
Do you provide a Certificate of Analysis (CoA) with each shipment?
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Yes. Every batch of L-Amethopterin hydrate ships with a Certificate of Analysis covering assay, identity and purity tests, plus pharmacopoeia conformance where applicable. MSDS and TDS documents are available on request before order placement.
How should L-Amethopterin hydrate be stored?
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Store L-Amethopterin hydrate in its original sealed container in a cool, dry place away from direct sunlight and incompatible materials, in line with the storage guidance on the Safety Data Sheet. Reseal between dispensings.
What is L-Amethopterin hydrate used for?
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L-Amethopterin hydrate is used in chemical synthesis applications across pharmaceutical, research and industrial settings. Our technical team can advise on suitability for your specific process.
How do I request a quote for L-Amethopterin hydrate?
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Request a quote with your required grade, quantity and destination via https://www.techservesolutions.in/contact or email info@techservesolutions.in. We respond with specifications, a Certificate of Analysis and pricing.
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