Ko143 hydrate
Ko143 hydrate (CAS: 461054-93-3) is a research chemical with the molecular formula C26H35N3O5 · xH2O. It presents as a white to off-white powder, soluble in DMSO. This compound is recognised for its role in studies related to drug efflux pumps and multi-drug resistance, making it a valuable tool in cell biology and neuroscience research for investigating cellular transport mechanisms and potential therapeutic targets.
- IUPAC
- (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1′,2′:1,6]pyrido[3,4- b]indole-3-propanoic acid 1,1-dimethylethyl ester hydrate
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Drug Efflux Pump Modulator
Ko143 hydrate serves as a key research compound for studying the function and inhibition of drug efflux pumps, particularly the MRP (multidrug resistance-associated protein) family. Its use aids in understanding drug transport and resistance mechanisms in cells.
Cellular Transport Research
This compound is utilised in cell biology and neuroscience to investigate complex cellular transport processes. It helps researchers probe the intricacies of how substances move across cell membranes and within cellular systems.
Multi-Drug Resistance Studies
Ko143 hydrate is instrumental in research focused on multi-drug resistance (MDR) in various biological contexts. By modulating transporter activity, it allows for deeper insights into the mechanisms contributing to drug resistance in disease states.
Approved Therapeutics Development
As a compound identified within the 'Approved Therapeutics/Drug Candidates' category, Ko143 hydrate is relevant for preclinical research and development activities aimed at new therapeutic agents.
| Molecular weight | 469.57 (anhydrous basis) |
|---|---|
| Empirical formula | C26H35N3O5 · xH2O |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to off-white |
| Solubility | DMSO: >10 mg/mL |
| Storage temperature | room temp |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ko143 hydrate used for?
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Ko143 hydrate is primarily used in research settings for studying drug efflux pumps, cellular transport mechanisms, and multi-drug resistance (MDR). It is a valuable tool in cell biology and neuroscience research.
What are the CAS number and formula for Ko143 hydrate?
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The CAS number for the anhydrous form is 461054-93-3. The empirical formula is C26H35N3O5 · xH2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ko143 hydrate with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeial grade unless explicitly stated.
How should Ko143 hydrate be handled safely?
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Ko143 hydrate is classified as a Warning substance, with hazards including skin irritation (H315), eye irritation (H319), and respiratory tract irritation (H335). Handle with appropriate personal protective equipment in a well-ventilated area. Avoid breathing dust and ensure proper disposal.
Is Ko143 hydrate a controlled substance?
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The provided data does not indicate that Ko143 hydrate is a controlled substance. However, users should always verify local regulations.
How is Ko143 hydrate shipped and exported?
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Ko143 hydrate is typically stored at room temperature and is available for global export by Tech Serve Solutions. Specific packaging and shipping details can be provided upon request.
How can I request a sample or quote for Ko143 hydrate?
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To request a sample or obtain a quote for Ko143 hydrate, please contact our sales team through the website or by phone. Our experts will assist you with your inquiry.
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