Kirromycin from Streptomyces collinus

CAS 50935-71-2C43H60N2O12Biochemicals & Reagents

Kirromycin from Streptomyces collinus (CAS: 50935-71-2, Formula: C43H60N2O12) is a polyketide antibiotic. Produced by Streptomyces collinus, it is recognised for its role in stimulating GTPase action of EF-Tu in specific experimental contexts. Kirromycin is employed in research to investigate bacterial protein synthesis, particularly at the level of elongation factor EF-Tu-GDP release, offering insights into microbial molecular mechanisms.

IUPAC: Antibiotic Myc-8003,Mocimycin

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Kirromycin from Streptomyces collinus (C43H60N2O12) — chemical structure, CAS 50935-71-2; Life Science, fine chemical supplied by Tech Serve Solutions

AntibacterialAntibioticsAntibiotics A to ZAntibiotics G-MBioactive Small MoleculesBiochemicals and ReagentsCell BiologyChemical Structure ClassMechanism of Action

01 /Applications

Research into Protein Synthesis

Kirromycin is utilised in biochemical and molecular biology research to study the mechanisms of bacterial protein synthesis. It specifically targets the elongation factor EF-Tu, aiding in the understanding of its GTPase activity and GDP release.

GTPase Activity Studies

This compound serves as a tool to stimulate and observe the GTPase action of EF-Tu, particularly in the absence of programmed ribosomes, as demonstrated in studies with Thermus thermophilus.

Investigating Antibiotic Mechanisms

As an antibiotic produced by Streptomyces collinus, Kirromycin can be studied to elucidate its mode of action and its interaction with bacterial cellular machinery, contributing to the broader field of antibiotic research.

02 /Properties

Molecular weight	796.94
Empirical formula	C43H60N2O12
Assay	≥90% (HPLC)
Storage temperature	−20°C
Application	Kirromycin is a polyketide antibiotic which is produced by the actinomycetes Streptomyces collinus. Kirromycin has been used to stimulate GTPase action of EF-Tu in the absence of programmed ribosomes in Thermus thermophilus1. Kirromycin is used to study bacterial protein synthesis at the level of elongation factor EF-Tu-GDP release.

03 /Identifiers & registry

CAS number

50935-71-2

MDL number

MFCD00467139

04 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

05 /Frequently asked questions

What is Kirromycin from Streptomyces collinus used for?

Kirromycin from Streptomyces collinus (CAS: 50935-71-2) is used in research to study bacterial protein synthesis, specifically the elongation factor EF-Tu's GTPase activity and GDP release mechanism.

What are the CAS number and formula for Kirromycin?

The CAS number for Kirromycin from Streptomyces collinus is 50935-71-2, and its empirical formula is C43H60N2O12.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Kirromycin with a purity of ≥90% (HPLC). This product is intended for research and laboratory use, and TSS does not represent it as USP, BP, EP, or other pharmacopoeial grades.

What are the safety and handling recommendations for Kirromycin?

Kirromycin is classified under WGK Germany 3. Handle with appropriate personal protective equipment in a well-ventilated area. Consult the Safety Data Sheet (SDS) for detailed hazard information and handling procedures.

How is Kirromycin shipped and exported?

Tech Serve Solutions professionally packs, ships, and exports Kirromycin globally, adhering to all relevant regulations for chemical transport. Our experienced logistics team ensures safe and timely delivery.

How can I request a quote or sample for Kirromycin?

To request a quote or a sample of Kirromycin, please contact our sales team via the website or email. Provide your contact details and the quantity or sample size required.