Kenpaullone
Kenpaullone (CAS: 142273-20-9; Formula: C16H11BrN2O; Molar Mass: 327.18) is a bioactive small molecule primarily investigated for its role in cell biology. It functions as an inhibitor, notably targeting Cyclin-Dependent Kinases (CDKs) and GSK-3β. Its applications lie in fundamental research, particularly in studies concerning apoptosis, cell cycle regulation, and cell signalling pathways.
- IUPAC
- 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one,NSC 664704
Cell Cycle Regulation Research
Kenpaullone is utilised in scientific research to investigate the mechanisms of cell cycle progression and arrest. It serves as a tool to study the function of CDKs, key regulators of cell division.
Apoptosis Studies
This compound finds application in research focused on programmed cell death (apoptosis). It can be employed to explore the signalling cascades that lead to or inhibit apoptosis in cellular models.
Kinase Inhibition Studies
As a known inhibitor of kinases like GSK-3β, Kenpaullone is valuable for researchers studying the role of these enzymes in various biological processes and disease pathways.
Neuroscience Research
Kenpaullone's inhibitory effects on certain kinases may be relevant in neuroscience research, particularly for exploring signalling pathways implicated in neurological functions and disorders.
| Molecular weight | 327.18 |
|---|---|
| Empirical formula | C16H11BrN2O |
| Assay | ≥99% |
| Colour | yellow |
| Solubility | DMSO: soluble18 mg/mL, clear, yellow |
| Storage temperature | 2-8°C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... CDC2(983)mouse ... Gsk3b(56637)rat ... Gsk3b(84027) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Kenpaullone primarily used for?
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Kenpaullone is primarily used in research settings to study cell cycle regulation, apoptosis, and as an inhibitor of kinases such as CDKs and GSK-3β.
What are the CAS number and chemical formula for Kenpaullone?
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The CAS number for Kenpaullone is 142273-20-9, and its chemical formula is C16H11BrN2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Kenpaullone with an assay of ≥99%. This product is intended for research use and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety considerations when handling Kenpaullone?
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Kenpaullone is classified with a GHS07 symbol and 'Warning' signal word, with hazard statements H315, H319, and H335, indicating it may cause skin irritation, serious eye irritation, and respiratory irritation. Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used. Handle in a well-ventilated area.
How is Kenpaullone stored and shipped?
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Kenpaullone should be stored at 2-8°C. It is supplied by Tech Serve Solutions as a fine chemical for laboratory and research export.
How can I request a sample or quote for Kenpaullone?
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To request a sample or a quotation for Kenpaullone, please contact the Tech Serve Solutions sales team via our website or listed contact details.
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