Hemicholinium-3
Hemicholinium-3 (CAS: 312-45-8, C24H34Br2N2O4) is a white solid chemical compound with a molecular weight of 574.35 g/mol. Primarily recognised for its role in neuroscience research, it functions as a specific inhibitor of high-affinity choline uptake. This action makes it a valuable tool for studying cholinergic neurotransmission and the mechanisms of acetylcholine synthesis and release in various biological systems.
- IUPAC
- 2,2′-(4,4′-Biphenylene)bis(2-hydroxy-4,4-dimethylmorpholinium bromide)
Neuroscience Research
Hemicholinium-3 is widely employed in neuroscience to investigate the dynamics of cholinergic neurotransmission. Its ability to block choline uptake helps researchers elucidate the processes of acetylcholine synthesis and release, crucial for understanding neuronal function and dysfunction.
Cell Biology Studies
As a selective inhibitor, Hemicholinium-3 serves as a vital reagent in cell biology for probing the function of choline transporters. This is essential for studying cellular energy metabolism and signalling pathways influenced by acetylcholine.
Pharmacological Tool
This compound acts as a pharmacological tool to modulate cholinergic systems. It allows for the in-depth study of how disruptions in choline availability affect neuronal activity and neurotransmitter levels in experimental models.
| Molecular weight | 574.35 |
|---|---|
| Empirical formula | C24H34Br2N2O4 |
| Assay | ≥95% (HPLC) |
| Form | solid |
| Colour | white |
| Solubility | ethanol: soluble1.3 mg/mLH2O: soluble10 mg/mL |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23/24/25-36/37/38 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Hemicholinium-3 used for?
+
Hemicholinium-3 is used in neuroscience and cell biology research to inhibit high-affinity choline uptake, thereby studying cholinergic neurotransmission, acetylcholine synthesis, and release.
What is the CAS number and formula for Hemicholinium-3?
+
The CAS number for Hemicholinium-3 is 312-45-8, and its empirical formula is C24H34Br2N2O4.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Hemicholinium-3 with an assay of ≥95% (HPLC). This product is supplied for research and laboratory use. TSS does not represent it as USP, BP, EP, or other pharmacopoeia grades.
How should Hemicholinium-3 be handled safely?
+
Hemicholinium-3 is a Danger signal word substance classified with hazards H301 + H311 + H331 (Toxic if swallowed, in contact with skin or if inhaled), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Always use appropriate personal protective equipment including eyeshields, faceshields, gloves, and a P2 respirator. Handle only in a well-ventilated area or under a fume hood.
How is Hemicholinium-3 packed, shipped, and exported?
+
Hemicholinium-3 is packed and shipped according to international regulations for hazardous materials, specifically UN 2811, Class 6.1, Packing Group II. Tech Serve Solutions is an experienced global supplier and exporter of fine chemicals.
How can I request a sample or quote for Hemicholinium-3?
+
To request a sample or a quotation for Hemicholinium-3, please contact the Tech Serve Solutions sales team through our website or by direct inquiry. Please specify the required quantity and your delivery location.
▶ Related products
(−)-Curcumol
C15H24O2
Cell Biology
(±) Clopidogrel hydrogensulfate
Cell Biology
(±)-L-Alliin
C6H11NO3S
Cell Biology
(±)-2-Amino-4-phosphonobutyric acid
C4H10NO5P
Cell Biology
(±)-2-Methylarachidonoyl-2′-fluoroethylamide
C23H38NOF
Cell Biology
(±)-3,4-Methylenedioxy-N-ethylamphetamine hydrochloride
Cell Biology
(±)-3,4-Methylenedioxyamphetamine hydrochloride
Cell Biology
(±)-3,4-Methylenedioxymethamphetamine hydrochloride
Cell Biology
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis