HDMA
HDMA (CAS: 958029-37-3, Formula: C12H17F6N6O2P, MW: 422.27) is a phosphonium-based peptide coupling reagent. It is recognised for its increased coupling efficiency and reduced racemisation compared to similar reagents like HATU. HDMA is an invaluable tool in chemical synthesis, particularly within peptide chemistry for the formation of amide bonds. It is supplied by TSS with a minimum assay of 99%.
- IUPAC
- 1-[(Dimethylamino)(morpholino)methylene]-1H-[1,2,3]triazolo[4,5-b]pyridine-1-ium 3-oxide hexafluorophosphate,N-methyl-N-[4-morpholinyl(3-oxido-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl)methylene]methanaminium, hexafluorophosphate
- Synonyms
- 1-\"[[(1,1-Dimethylethyl)amino]methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate, N-methyl-N-[4-morpholinyl(3-oxido-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl)methylene]methanaminium, hexafluorophosphate
Peptide Coupling Agent
HDMA is employed as a highly efficient reagent for forming peptide bonds. Its structure is designed to promote rapid coupling while minimising the undesirable epimerisation of chiral amino acid residues.
Chemical Synthesis
Beyond peptide synthesis, HDMA finds application in general organic synthesis where the formation of amide or ester bonds is required under mild conditions. It aids in achieving high yields and purity in complex molecular constructions.
Chemical Biology Research
In chemical biology, HDMA can be utilised for synthesising modified peptides or peptidomimetics for use in biological studies. Its effectiveness supports the creation of complex biomolecules for research purposes.
| Molecular weight | 422.27 |
|---|---|
| Empirical formula | C12H17F6N6O2P |
| Assay | 99% |
| Storage temperature | 2-8°C |
| Application | Peptide coupling agent with increased coupling efficiency and lower racemization compared to HATU. |
| Melting point | 218 °C (decomposition) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is HDMA used for?
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HDMA is primarily used as an efficient peptide coupling agent in chemical synthesis, offering increased coupling efficiency and lower racemisation compared to other reagents like HATU.
What are the CAS number and formula for HDMA?
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The CAS number for HDMA is 958029-37-3 and its empirical formula is C12H17F6N6O2P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies HDMA with a minimum assay of 99%. We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should HDMA be handled safely?
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HDMA is classified as a Warning substance, harmful if swallowed, in contact with skin, or if inhaled (H302 + H312 + H332), causes skin irritation (H315), causes serious eye irritation (H319), and may cause respiratory irritation (H335). Always handle with appropriate personal protective equipment, including gloves, eye protection, and respiratory protection in a well-ventilated area. Store at 2-8°C.
How is HDMA packed and shipped?
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HDMA is typically packed in appropriate containers for chemical reagents and can be exported globally by Tech Serve Solutions, adhering to all relevant shipping regulations.
How can I request a quote or sample for HDMA?
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To request a quote or sample for HDMA, please contact our sales team via the website or by phone, providing your contact details and required quantity.
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