Glutarimide
Glutarimide (CAS: 1121-89-7, Formula: C5H7NO2, MW: 113.11) is a cyclic imide and a key heterocyclic building block. It serves as a crucial reactant in various organic syntheses. Its applications span from thionation reactions and the synthesis of complex pharmaceutical intermediates, such as those for beta-adrenoceptor ligands and sitagliptin manufacture, to the enantioselective synthesis of natural products and the formation of alpha-fluoro-alpha amino amides. Glutarimide is essential for advanced chemical synthesis.
- IUPAC
- 2,6-Piperidinedione,NSC 58190
Thionation Reactions
Glutarimide serves as a reactant in thionation reactions, a process used to introduce sulfur atoms into organic molecules, which is valuable in synthetic chemistry.
Biocatalytic Asymmetric Synthesis
It is employed in the biocatalytic asymmetric synthesis of chiral amines, notably applied in the manufacture of sitagliptin, a key pharmaceutical compound.
Synthesis of Beta-Adrenoceptor Ligands
Glutarimide is a precursor in the synthesis of various beta-adrenoceptor ligands, which are important targets in medicinal chemistry research.
Enantioselective Synthesis of Alkaloids
The compound facilitates the enantioselective synthesis of complex natural products, such as securinega alkaloids, requiring precise stereochemical control.
Amide Cyclopropanation Reactions
Glutarimide is utilised in intramolecular amidocyclopropanation reactions, enabling the construction of cyclopropane rings within molecular structures.
Alpha-Fluoro-Alpha Amino Amides Synthesis
It plays a role in the synthesis of alpha-fluoro-alpha amino amides, valuable intermediates with potential applications in pharmaceuticals and materials science.
| Molecular weight | 113.11 |
|---|---|
| Empirical formula | C5H7NO2 |
| Assay | 98% |
| Application | Reactant for: Thionations1 Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture2 Synthesis of β-adrenoceptor ligands3 Enantioselective synthesis of securinega alkaloids4 Intramolecular amidocyclopropanation reactions5 Synthesis of alpha-fluoro-alpha amino amides6 |
| Melting point | 155-157 °C(lit.) |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Glutarimide used for?
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Glutarimide (CAS: 1121-89-7) is used as a reactant in various organic syntheses, including thionations, biocatalytic asymmetric synthesis for sitagliptin manufacture, synthesis of beta-adrenoceptor ligands, enantioselective synthesis of securinega alkaloids, intramolecular amidocyclopropanation reactions, and synthesis of alpha-fluoro-alpha amino amides.
What are the CAS number and formula for Glutarimide?
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The CAS number for Glutarimide is 1121-89-7, and its empirical formula is C5H7NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Glutarimide with a purity of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety considerations for handling Glutarimide?
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Glutarimide (WGK: 3) requires careful handling. It is classified as hazardous. Please consult the Safety Data Sheet (SDS) for comprehensive information on hazards, protective measures, and emergency procedures before use.
How is Glutarimide packed and shipped?
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Glutarimide is available for export globally. Specific packing and shipping details will be provided based on your order requirements and destination, adhering to all relevant transport regulations.
How can I request a quote or sample for Glutarimide?
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To request a quote or a sample of Glutarimide, please visit the product page on the Tech Serve Solutions website and use the designated 'Request a Quote' or 'Sample Request' forms, or contact our sales team directly.
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