Fluocinonide
Fluocinonide (CAS 356-12-7), a potent synthetic fluorinated corticosteroid with the formula C26H32F2O7 and a molecular weight of 494.52 g/mol, is supplied as a white to tan powder. It is recognised for its anti-inflammatory, anti-pruritic, and vasoconstrictive properties. Primarily utilised in dermatological research and formulation, it serves as a key intermediate and reference standard in pharmaceutical development and analytical chemistry.
- IUPAC
- (6α,11β,16α)-21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione,Lonide
- Synonyms
- Lonide
Dermatological Research
Fluocinonide is extensively used in research settings to study the mechanisms of corticosteroid action on skin inflammation and related dermatological conditions. Its potent anti-inflammatory effects make it a valuable tool for investigating cellular signalling pathways in skin.
Pharmaceutical Intermediate
As a synthetic corticosteroid, Fluocinonide serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. Its specific chemical structure allows for further modification in the development of novel therapeutic agents, particularly in topical formulations.
Analytical Reference Standard
The high purity of Fluocinonide supplied by TSS makes it suitable as an analytical reference standard. It is used for method development, validation, and quality control in the pharmaceutical industry to ensure the identity, purity, and potency of related drug products.
| Molecular weight | 494.52 |
|---|---|
| Empirical formula | C26H32F2O7 |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to tan |
| Solubility | DMSO: ≥19 mg/mL |
| Optical activity | [α]/D +75 to +90°, c = 1 in dichloromethane |
| Storage temperature | 2-8°C |
Hazard statements
- H300Fatal if swallowed
- H361Suspected of damaging fertility or the unborn child
Precautionary statements
- P264Wash thoroughly after handling
- P281Use personal protective equipment as required
- P301IF SWALLOWED
| Transport (UN / ADR) | UN 2811 6.1 / PGII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 63-28 |
| Safety statements (S) | 22-25-28-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fluocinonide primarily used for?
+
Fluocinonide is primarily used in dermatological research, as a pharmaceutical intermediate, and as an analytical reference standard due to its potent anti-inflammatory properties.
What are the CAS number and formula for Fluocinonide?
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The CAS number for Fluocinonide is 356-12-7, and its empirical formula is C26H32F2O7.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fluocinonide with an assay of ≥98% (HPLC). TSS does not represent this product as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated.
How should Fluocinonide be handled safely?
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Fluocinonide is a dangerous substance; inhalation, ingestion, or skin contact can be fatal. Handle with extreme caution in a well-ventilated area, using appropriate personal protective equipment, including respiratory protection. Refer to the Safety Data Sheet (SDS) for detailed handling procedures.
Is Fluocinonide a controlled substance?
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The provided safety data indicates Fluocinonide is toxic if swallowed (H300) and may damage fertility or the unborn child (H361). It is classified under UN 2811, Hazard Class 6.1, Packing Group II. Users should verify local regulations regarding its controlled status.
How is Fluocinonide packed and shipped?
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Fluocinonide is packaged securely for transport and exported by TSS in compliance with international shipping regulations for hazardous materials.
How can I request a sample or quote for Fluocinonide?
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To request a sample or a quote for Fluocinonide, please contact the Tech Serve Solutions sales department through our official website or designated contact channels.
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