Ethyl indole-2-carboxylate
Ethyl indole-2-carboxylate (CAS: 3770-50-1, Formula: C11H11NO2) is a high-purity (97%) organic compound from the indole family. As a key heterocyclic building block, it serves as a crucial reactant in the synthesis of various biologically active molecules. Its applications span the development of therapeutic agents, including CRTH2 receptor antagonists, indoleamine 2,3-dioxygenase (IDO) inhibitors, and compounds targeting cannabinoid receptors, demonstrating its significant utility in medicinal chemistry and pharmaceutical research.
- IUPAC
- 2-Ethoxycarbonylindole,NSC 10076
- Synonyms
- 2-Ethoxycarbonylindole2-Ethoxycarbonyl-1H-indoleNSC 100762-Indolecarboxylic acid ethyl ester
Synthesis of CRTH2 Receptor Antagonists
Ethyl indole-2-carboxylate is a vital starting material for the preparation of CRTH2 receptor antagonists. These compounds are investigated for their potential in treating allergic inflammatory diseases.
Development of Indoleamine 2,3-Dioxygenase (IDO) Inhibitors
This indole derivative is employed in the synthesis of indoleamine 2,3-dioxygenase (IDO) inhibitors. IDO is a key enzyme in immune modulation, and its inhibitors are explored for cancer immunotherapy.
Preparation of Cannabinoid CB1 Receptor Antagonists
The compound serves as a precursor in the development of cannabinoid CB1 receptor antagonists. These agents are studied for their potential therapeutic applications in metabolic and neurological disorders.
Synthesis of Anti-inflammatory Agents
Ethyl indole-2-carboxylate is utilised in the creation of inhibitors of Human Reticulocyte 15-Lipoxygenase-1, which are investigated for their anti-inflammatory properties.
Antihypertriglyceridemic Agents
It is a precursor for N-(benzoylphenyl)-1H-indole-2-carboxamides, which have demonstrated potential as potent antihypertriglyceridemic agents.
Antiproliferative and Kinase Inhibitors
This building block is used in the synthesis of antiproliferative agents against human leukemia K562 cells and inhibitors of p38 MAP kinase, relevant in cancer and inflammatory disease research.
| Molecular weight | 189.21 |
|---|---|
| Empirical formula | C11H11NO2 |
| Assay | 97% |
| Application | Reactant for preparation of:• CRTH2 receptor antagonists1• Indoleamine 2,3-dioxygenase (IDO) inhibitors2• Cannabinoid CB1 receptor antagonists3• Inhibitors of Human Reticulocyte 15-Lipoxygenase-14• N-(benzoylphenyl)-1H-indole-2-carboxamides as potent antihypertriglyceridemic agents5• A antiproliferative agent against human leukemia K562 cells6• Inhibitors of p38 MAP kinase7• Acetolactate synthase inhibitors8 |
| Melting point | 122-125 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl indole-2-carboxylate used for?
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Ethyl indole-2-carboxylate (CAS: 3770-50-1) is a chemical intermediate primarily used as a reactant in the synthesis of various biologically active compounds, including CRTH2 receptor antagonists, IDO inhibitors, cannabinoid receptor antagonists, and antiproliferative agents.
What are the CAS number and formula for Ethyl indole-2-carboxylate?
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The CAS number for Ethyl indole-2-carboxylate is 3770-50-1, and its empirical formula (Hill notation) is C11H11NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl indole-2-carboxylate with an assay of 97%. This product is not supplied as USP, BP, EP, or any pharmacopoeia grade.
What are the safety and handling recommendations for Ethyl indole-2-carboxylate?
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Handle Ethyl indole-2-carboxylate with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. This compound has a WGK Germany classification of 3.
How is Ethyl indole-2-carboxylate packed, shipped, and exported?
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Tech Serve Solutions offers Ethyl indole-2-carboxylate, which is carefully packed for secure transit. We are experienced global exporters of fine chemicals and laboratory reagents.
How can I request a sample or quote for Ethyl indole-2-carboxylate?
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To request a sample or a quote for Ethyl indole-2-carboxylate, please contact our sales department through the website or by phone.
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